{"product_id":"human-m-phase-phosphoprotein-8-mphosph8-elisa-kit-bhe13703779","title":"Human M-phase phosphoprotein 8 (MPHOSPH8) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman M-phase phosphoprotein 8 (MPHOSPH8) ELISA Kit has high sensitivity and excellent specificity for detection of Human MPHOSPH8. No significant cross-reactivity or interference between Human MPHOSPH8 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMPHOSPH8 (M-Phase Phosphoprotein 8) is a Protein Coding gene. GO annotations related to this gene include methylated histone binding. Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338636157293,"sku":"KTE61564-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338829324653,"sku":"KTE61564-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338829357421,"sku":"KTE61564-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338829390189,"sku":"KTE61564-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61564.png?v=1778954771","url":"https:\/\/www.ebiohippo.com\/products\/human-m-phase-phosphoprotein-8-mphosph8-elisa-kit-bhe13703779","provider":"BioHippo","version":"1.0","type":"link"}