{"product_id":"human-macrophage-scavenger-receptor-types-i-and-ii-msr1-elisa-kit-bhe13703737","title":"Human Macrophage scavenger receptor types I and II (MSR1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Macrophage scavenger receptor types I and II (MSR1) ELISA Kit has high sensitivity and excellent specificity for detection of Human MSR1. No significant cross-reactivity or interference between Human MSR1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eMSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338634191213,"sku":"KTE61522-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338826375533,"sku":"KTE61522-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338826408301,"sku":"KTE61522-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338826441069,"sku":"KTE61522-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61522.png?v=1778954766","url":"https:\/\/www.ebiohippo.com\/products\/human-macrophage-scavenger-receptor-types-i-and-ii-msr1-elisa-kit-bhe13703737","provider":"BioHippo","version":"1.0","type":"link"}