{"product_id":"human-mediator-of-rna-polymerase-ii-transcription-subunit-12-med12-elisa-kit-bhe13703886","title":"Human Mediator of RNA polymerase II transcription subunit 12 (MED12) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Mediator of RNA polymerase II transcription subunit 12 (MED12) ELISA Kit has high sensitivity and excellent specificity for detection of Human MED12. No significant cross-reactivity or interference between Human MED12 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by MED12, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in MED12 cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338639204717,"sku":"KTE61671-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338840203629,"sku":"KTE61671-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338840236397,"sku":"KTE61671-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338840269165,"sku":"KTE61671-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61671.png?v=1778954782","url":"https:\/\/www.ebiohippo.com\/products\/human-mediator-of-rna-polymerase-ii-transcription-subunit-12-med12-elisa-kit-bhe13703886","provider":"BioHippo","version":"1.0","type":"link"}