{"product_id":"human-multidrug-resistance-associated-protein-4-abcc4-elisa-kit-bhe13703077","title":"Human Multidrug resistance-associated protein 4 (ABCC4) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Multidrug resistance-associated protein 4 (ABCC4) ELISA Kit has high sensitivity and excellent specificity for detection of Human ABCC4. No significant cross-reactivity or interference between Human ABCC4 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eABCC4, also known as MRP4, belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.\u003c\/p\u003e\u003cp\u003eThe insertion was attributed to 2 additional exons, designated 1a and 1b, that produced premature termination codons (PTCs). A comparison of human, monkey, and rodent ABCC4 genes revealed that these same PTC-producing exons were also highly conserved in evolution. In vitro inhibition of protein synthesis (using puromycin or anisomycin) selectively reduced nonsense-mediated mRNA decay of PTC-containing ABCC4 transcripts in all cell lines tested.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338612466029,"sku":"KTE60861-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338761199981,"sku":"KTE60861-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338761232749,"sku":"KTE60861-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338761265517,"sku":"KTE60861-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-multidrug-resistance-associated-protein-4-abcc4-elisa-kit-bhe13703077","provider":"BioHippo","version":"1.0","type":"link"}