{"product_id":"human-neutrophil-gelatinase-associated-lipocalin-protein-bhp10506058","title":"human Neutrophil gelatinase-associated lipocalin protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative human lipocalin-2 \/ NGAL (LCN2) is purified from human urine and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Other Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eLipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted lipocalin involved in innate immune responses and iron trafficking through siderophore binding. It is produced by multiple cell types and is frequently studied in inflammation and epithelial stress contexts.\u003c\/p\u003e\u003cp\u003eIron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eInnate immunity and host–microbe interactions where siderophore sequestration links nutrition to pathogen control.\u003c\/li\u003e \u003cli\u003eRenal and epithelial injury models where LCN2\/NGAL is frequently profiled as a responsive secreted factor (RUO).\u003c\/li\u003e \u003cli\u003eMetabolic inflammation research examining LCN2 as a mediator or marker in adipose and systemic inflammatory signaling.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eImmunoassay standards\/controls for LCN2 quantification in cell culture supernatants or biological matrices.\u003c\/li\u003e \u003cli\u003eBinding and mechanistic studies around siderophore\/iron handling and receptor-mediated uptake concepts.\u003c\/li\u003e \u003cli\u003ePathway studies connecting inflammatory cytokines, epithelial stress, and secreted protein programs.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eLCN2 can exist in different ligand-bound states; ligand occupancy may influence functional interpretations.\u003c\/li\u003e \u003cli\u003eMatrix effects (serum, urine, mucosal fluids) can change apparent measurements; interpret with appropriate controls.\u003c\/li\u003e \u003cli\u003eReported biology can be tissue- and context-specific; avoid over-interpreting changes without complementary markers.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=lipocalin-2 LCN2 NGAL - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=lipocalin-2 LCN2 NGAL - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=lipocalin-2 LCN2 NGAL%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052975513965,"sku":"CSB-NP068341h-1G","price":173335.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052975546733,"sku":"CSB-NP068341h-100MG","price":26665.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052975579501,"sku":"CSB-NP068341h-10MG","price":3335.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052975612269,"sku":"CSB-NP068341h-1MG","price":630.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP068341h-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/human-neutrophil-gelatinase-associated-lipocalin-protein-bhp10506058","provider":"BioHippo","version":"1.0","type":"link"}