{"product_id":"human-pescadillo-homolog-pes1-elisa-kit-bhe13703463","title":"Human Pescadillo homolog (PES1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Pescadillo homolog (PES1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PES1. No significant cross-reactivity or interference between Human PES1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003ePES1 is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. The gene plays a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression.The deduced 588-amino acid PES1 protein is 74% identical to the zebrafish sequence. The authors noted the presence of a highly acidic region at the C terminus and that the protein has an alpha-helix structure. Immunoblot analysis showed that PES1 is expressed as an unmodified 72-kD protein and a SUMO1-modified 92-kD protein. In situ hybridization analysis revealed wide and high expression of Pes1 in embryonic mouse brain and spinal cord. Pes1 expression was upregulated in malignant, late-passage mouse astrocytes.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338625245549,"sku":"KTE61247-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338799047021,"sku":"KTE61247-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338799079789,"sku":"KTE61247-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338799112557,"sku":"KTE61247-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61247.png?v=1778954738","url":"https:\/\/www.ebiohippo.com\/products\/human-pescadillo-homolog-pes1-elisa-kit-bhe13703463","provider":"BioHippo","version":"1.0","type":"link"}