{"product_id":"human-phosphatidylinositol-binding-clathrin-assembly-protein-picalm-elisa-kit-bhe13703429","title":"Human Phosphatidylinositol-binding clathrin assembly protein (PICALM) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Phosphatidylinositol-binding clathrin assembly protein (PICALM) ELISA Kit has high sensitivity and excellent specificity for detection of Human PICALM. No significant cross-reactivity or interference between Human PICALM and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eDreyling et al. (1996) identified a breakpoint on chromosome 11 involving the previously unknown gene, CALM. CALM has a very high homology to the murine clathrin assembly protein ap3. Mao et al. (2001) determined the crystal structure of the N-terminal domain (the NAP domain) of the Drosophila Lap protein, which is homologous to human PICALM. The structure revealed a novel fold consisting of a large double layer of sheets of 10 alpha helices and a unique site for binding phosphoinositides.This motif is found in other proteins predicted to have domains of similar structure (e.g., Huntingtin-interacting protein-1). The structure is in part similar to the epsin N-terminal (ENTH) domain, but epsin lacks the phosphatidylinositol-4,5-bisphosphate-binding site.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338624393581,"sku":"KTE61213-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338795311469,"sku":"KTE61213-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338795344237,"sku":"KTE61213-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338795377005,"sku":"KTE61213-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61213.png?v=1778954734","url":"https:\/\/www.ebiohippo.com\/products\/human-phosphatidylinositol-binding-clathrin-assembly-protein-picalm-elisa-kit-bhe13703429","provider":"BioHippo","version":"1.0","type":"link"}