{"product_id":"human-poly-adp-ribose-polymerase-1-bhp16300070","title":"Human Poly(ADP-ribose) Polymerase-1","description":"\u003cstyle\u003e.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}.bhp-desc p{margin:0 0 12px}.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}.bhp-desc .bhp-spec-table th{text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}.bhp-desc ol,.bhp-desc ul{margin:0 0 12px 20px}\u003c\/style\u003e\u003cdiv class=\"bhp-desc\"\u003e\n\u003cspan class=\"bhp-cat-pill\"\u003eEnzyme\u003c\/span\u003e\u003cp\u003ePoly(ADP-ribose) polymerase-1 (PARP-1) responds to DNA damage by making poly ADP-ribose (PAR), which is attached to PARP-1 itself and to many acceptor proteins. Strong PARP-1 activation depletes NAD+ and produces toxic PAR, which can lead to cell death. PARP-1 is an anticancer drug target and a possible target in other conditions with heavy DNA damage, such as stroke and ischemia-reperfusion injury.\u003c\/p\u003e\n\u003ch2\u003eProduct Description\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003e100 assays (17 µl) – PARP-100\u003c\/th\u003e\n\u003ctd\u003e17 µl of 0.7 mg\/ml human poly(ADP-ribose) polymerase-1 (PARP-1).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003e1000 assays (170 µl) – PARP-1000\u003c\/th\u003e\n\u003ctd\u003e170 µl of 0.7 mg\/ml human poly(ADP-ribose) polymerase-1 (PARP-1).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eSpecifications\u003c\/h2\u003e\n\u003ctable class=\"bhp-spec-table\"\u003e\n\u003ctr\u003e\n\u003cth\u003eProduct Type\u003c\/th\u003e\n\u003ctd\u003ePoly(ADP-ribose) Polymerases\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eOrganism\u003c\/th\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eConcentration\u003c\/th\u003e\n\u003ctd\u003e0.7 mg\/ml\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eAlternative Names\u003c\/th\u003e\n\u003ctd\u003ePARP-1\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eSizes\u003c\/th\u003e\n\u003ctd\u003e100 assays (17 µl), 1000 assays (170 µl)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eCatalog #\u003c\/th\u003e\n\u003ctd\u003ePARP-100, PARP-1000\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003ePlease contact us to confirm storage conditions.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003cth\u003eShipping\u003c\/th\u003e\n\u003ctd\u003eShipped frozen.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\n\u003ch2\u003eUse With\u003c\/h2\u003e\n\u003cp\u003eThis enzyme is used in the following ProFoldin assay kit:\u003c\/p\u003e\n\u003cul\u003e\u003cli\u003e\n\u003ca href=\"\/products\/human-poly-adp-ribose-polymerase-1-assay-kit-bht16300016\"\u003eHuman Poly (ADP-ribose) Polymerase-1 Assay Kit\u003c\/a\u003e (BHT16300016) — PAR100KE already includes this enzyme; PAR100K is enzyme-free and needs this product\u003c\/li\u003e\u003c\/ul\u003e\n\u003ch2\u003eProtocol\u003c\/h2\u003e\n\u003cp\u003eNo separate datasheet is available for this enzyme. The ProFoldin protocol “Human poly (ADP-ribose) polymerase-1 assay” (linked under Documents) shows how the enzyme is used in the matching assay kit.\u003c\/p\u003e\n\u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n\u003cdiv class=\"bhp-warning-box\"\u003eFor Research Use Only (RUO). Not for use in diagnostic or therapeutic procedures. This enzyme is shipped frozen. Follow standard laboratory safety practices.\u003c\/div\u003e\n\u003c\/div\u003e","brand":"ProFoldin","offers":[{"title":"100 assays (17 µl)","offer_id":67815136657773,"sku":"PARP-100","price":570.0,"currency_code":"USD","in_stock":true},{"title":"1000 assays (170 µl)","offer_id":67815138984301,"sku":"PARP-1000","price":3127.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-poly-adp-ribose-polymerase-1-bhp16300070","provider":"BioHippo","version":"1.0","type":"link"}