{"product_id":"human-poly-adp-ribose-polymerase-parp-elisa-kit-bhe13703518","title":"Human Poly ADP ribose polymerase (PARP) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Poly ADP ribose polymerase (PARP) ELISA Kit has high sensitivity and excellent specificity for detection of Human PARP1. No significant cross-reactivity or interference between Human PARP1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003ePARP is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.RP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress . This protein can be cleaved by many ICE-like caspases in vitroand is one of the main cleavage targets of caspase-3 in vivo . In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) .\u003c\/p\u003e\u003cp\u003ePARP1 is a chromatin-associated enzyme, poly-ADP ribose polymerase-1, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338626785645,"sku":"KTE61302-48T","price":359.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338804224365,"sku":"KTE61302-96T","price":619.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338804257133,"sku":"KTE61302-96TX5","price":2809.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338804289901,"sku":"KTE61302-96TX50","price":26209.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61302.png?v=1778954745","url":"https:\/\/www.ebiohippo.com\/products\/human-poly-adp-ribose-polymerase-parp-elisa-kit-bhe13703518","provider":"BioHippo","version":"1.0","type":"link"}