{"product_id":"human-programmed-cell-death-1-ligand-2-pdcd1lg2-elisa-kit-bhe13703495","title":"Human Programmed cell death 1 ligand 2 (PDCD1LG2) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Programmed cell death 1 ligand 2 (PDCD1LG2) ELISA Kit has high sensitivity and excellent specificity for detection of Human PDCD1LG2. No significant cross-reactivity or interference between Human PDCD1LG2 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eUsing flow cytometric analysis, Latchman et al. (2001) showed that the IgV region of mouse Pdl2, like Pdl1, binds to human PDCD1 but not to CTLA4, CD28 , or ICOS. Stimulation of mouse T cells with anti-CD3 and Pdl2 or Pdl1 resulted in inhibition of proliferation and cytokine production, and Pdl2 could inhibit T-cell receptor -CD28 signals at low antigen concentrations. Latchman et al. (2001) proposed that blocking of the PDL-PDCD1 pathway may enhance antitumor immunity, whereas stimulating this pathway may help downregulate graft rejection and autoimmune and allergic reactions.\u003c\/p\u003e\u003cp\u003eLatchman et al. (2001) mapped the PDL2 gene to chromosome 9p24.2, in close proximity to the PDL1 gene. Tseng et al. (2001) mapped the mouse Pdl2 gene to chromosome 19C2-C3.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338626097517,"sku":"KTE61279-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338801602925,"sku":"KTE61279-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338801635693,"sku":"KTE61279-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338801668461,"sku":"KTE61279-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61279.png?v=1778954744","url":"https:\/\/www.ebiohippo.com\/products\/human-programmed-cell-death-1-ligand-2-pdcd1lg2-elisa-kit-bhe13703495","provider":"BioHippo","version":"1.0","type":"link"}