{"product_id":"human-programmed-cell-death-protein-6-pdcd6-elisa-kit-bhe13703492","title":"Human Programmed cell death protein 6 (PDCD6) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Programmed cell death protein 6 (PDCD6) ELISA Kit has high sensitivity and excellent specificity for detection of Human PDCD6. No significant cross-reactivity or interference between Human PDCD6 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003ePDCD6 encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.ALG2 is expressed as a 22-kD protein before FAS activation and thereafter as a 19-kD protein, probably due to N-terminal cleavage. Confocal microscopy and immunoprecipitation analysis demonstrated that ALG2 translocates from the cytoplasmic membrane to the cytosol during FAS-induced apoptosis and then dissociates from FAS after activation.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338626228589,"sku":"KTE61276-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338801308013,"sku":"KTE61276-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338801340781,"sku":"KTE61276-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338801373549,"sku":"KTE61276-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61276.png?v=1778954742","url":"https:\/\/www.ebiohippo.com\/products\/human-programmed-cell-death-protein-6-pdcd6-elisa-kit-bhe13703492","provider":"BioHippo","version":"1.0","type":"link"}