{"product_id":"human-prolyl-4-hydroxylase-subunit-alpha-3-p4ha3-elisa-kit-bhe13703542","title":"Human Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) ELISA Kit has high sensitivity and excellent specificity for detection of Human P4HA3. No significant cross-reactivity or interference between Human P4HA3 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eP4HA3 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. P4HA3 has all residues necessary to bind the peptide substrate, to coordinate Fe(2+) and the 2-oxoglutarate cosubstrate, and for enzymatic activity. Processed P4HA3 contains 525 amino acids and shares 91% and 94% amino acid identity with rat and mouse P4ha3, respectively, and 35% and 37% identity with P4HA1 and P4HA2, respectively. Northern blot analysis detected a 2.7-kb P4HA3 transcript. Highest expression was in placenta, adult liver, and fetal skin, with lower levels in fetal liver, lung, and muscle. RT-PCR detected P4HA3 expression in all tissues examined, with highest expression in placenta and fetal kidney, liver, and lung. Expression of P4HA3 was much lower than that of P4HA1.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338627834221,"sku":"KTE61326-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338806616429,"sku":"KTE61326-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338806649197,"sku":"KTE61326-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338806681965,"sku":"KTE61326-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61326.png?v=1778954748","url":"https:\/\/www.ebiohippo.com\/products\/human-prolyl-4-hydroxylase-subunit-alpha-3-p4ha3-elisa-kit-bhe13703542","provider":"BioHippo","version":"1.0","type":"link"}