{"product_id":"human-protein-prune-homolog-prune-elisa-kit-bhe13703314","title":"Human Protein prune homolog (PRUNE) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Protein prune homolog (PRUNE) ELISA Kit has high sensitivity and excellent specificity for detection of Human PRUNE. No significant cross-reactivity or interference between Human PRUNE and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003ePRUNE, the human homologue of the Drosophila gene, is located in 1q21.3, a region highly amplified in human sarcomas, malignant tumours of mesenchymal origin. Prune protein interacts with the metastasis suppressor nm23-H1, but shows impaired affinity towards the nm23-H1 S120G mutant associated with advanced neuroblastoma.\u003c\/p\u003e\u003cp\u003ePrune may act as a negative regulator of nm23-H1 activity. PRUNE amplification was generally accompanied by high mRNA and moderate to high protein levels. The sarcoma samples expressed nm23-H1 mostly at low or moderate levels, whereas mRNA and protein levels were moderate to high in breast carcinomas. For the more aggressive sarcoma subtypes, 9\/13 patients with PRUNE amplification developed metastases.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338620461421,"sku":"KTE61098-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338783777133,"sku":"KTE61098-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338783809901,"sku":"KTE61098-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338783842669,"sku":"KTE61098-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE61098.png?v=1778954721","url":"https:\/\/www.ebiohippo.com\/products\/human-protein-prune-homolog-prune-elisa-kit-bhe13703314","provider":"BioHippo","version":"1.0","type":"link"}