{"product_id":"human-pygopus-homolog-1-pygo1-elisa-kit-bhe13703231","title":"Human Pygopus homolog 1 (PYGO1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Pygopus homolog 1 (PYGO1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PYGO1. No significant cross-reactivity or interference between Human PYGO1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eWNT signaling controls many fundamental processes during animal development. WNT transduction is mediated by the association of beta-catenin with nuclear TCF DNA-binding factors.Lgs encodes the homolog of human BCL9, and the authors provided genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin. The PYGO1 and PYGO2 proteins, which contain 419 and 406 amino acids, respectively, possess a highly conserved PHD finger that interacts with homology domain-1 (HD1) of BCL9. The findings suggested that the recruitment of PYGO permits beta-catenin to transcriptionally activate WNT target genes and raised the possibility that a deregulation of these events may play a causal role in the development of B-cell malignancies.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338618331501,"sku":"KTE61015-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338775224685,"sku":"KTE61015-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338775257453,"sku":"KTE61015-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338775290221,"sku":"KTE61015-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-pygopus-homolog-1-pygo1-elisa-kit-bhe13703231","provider":"BioHippo","version":"1.0","type":"link"}