{"product_id":"human-pyrroline-5-carboxylate-reductase-1-mitochondrial-pycr1-elisa-kit-bhe13703239","title":"Human Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) ELISA Kit has high sensitivity and excellent specificity for detection of Human PYCR1. No significant cross-reactivity or interference between Human PYCR1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003ePYCR1 catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.The 1,810-bp cDNA hybridized to a 1.85-kb mRNA in samples from human cell lines and predicated a 319-amino acid, 33.4-kD protein.\u003c\/p\u003e\u003cp\u003ePYCR1 protein colocalized with various mitochondrial markers, including delta-1-pyrroline-5-carboxylate synthetase (P5CS), which also belongs to the proline metabolic pathway. Knockdown of the orthologous genes in Xenopus and zebrafish led to epidermal hypoplasia and blistering that was accompanied by a massive increase in apoptosis.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338618233197,"sku":"KTE61023-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338776207725,"sku":"KTE61023-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338776240493,"sku":"KTE61023-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338776273261,"sku":"KTE61023-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-pyrroline-5-carboxylate-reductase-1-mitochondrial-pycr1-elisa-kit-bhe13703239","provider":"BioHippo","version":"1.0","type":"link"}