{"product_id":"human-rap-guanine-nucleotide-exchange-factor-4-rapgef4-elisa-kit-bhe13703194","title":"Human Rap guanine nucleotide exchange factor 4 (RAPGEF4) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Rap guanine nucleotide exchange factor 4 (RAPGEF4) ELISA Kit has high sensitivity and excellent specificity for detection of Human RAPGEF4. No significant cross-reactivity or interference between Human RAPGEF4 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eSequence analysis predicted that the 1,011-amino acid cAMP-GEFII protein contains an N-terminal cAMP-binding domain and a C-terminal GEF domain. Expression of cAMP-GEFI and cAMP-GEFII activated RAP1A after forskolin and 3-isobutyl-1-methylxanthine stimulation, independent of the protein kinase A pathway.\u003c\/p\u003e\u003cp\u003ecAMP-GEFI and cAMP-GEFII expression did not activate or only slightly activated other RAS superfamily members after stimulation. Northern blot analysis detected expression of a 4.4-kb cAMP-GEFII transcript that was most prominent in brain and adrenal gland. Within the brain, expression was strongest in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus, and cerebellum.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338616201581,"sku":"KTE60978-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338772177261,"sku":"KTE60978-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338772210029,"sku":"KTE60978-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338772242797,"sku":"KTE60978-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-rap-guanine-nucleotide-exchange-factor-4-rapgef4-elisa-kit-bhe13703194","provider":"BioHippo","version":"1.0","type":"link"}