{"product_id":"human-retinol-binding-protein-4-bhp10506059","title":"human Retinol-binding protein 4","description":"\u003ch2\u003eOverview\u003c\/h2\u003e \u003cp\u003eNative human RBP4 is purified from human urine and supplied as a research reagent. It is commonly used as a reference material in biochemical and analytical workflows, and to support interpretation when naturally occurring proteoforms (for example, glycosylation or other post‑translational modifications) may matter.\u003c\/p\u003e \u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e \u003cul\u003e \u003cli\u003e\n\u003cstrong\u003eNative-source preparation:\u003c\/strong\u003e Purified from a biological source, which can be useful when studying naturally occurring proteoforms and complex formation.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eMolecular form:\u003c\/strong\u003e Full length protein.\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Other Protein\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;95%(SDS-PAGE) (as reported).\u003c\/li\u003e \u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThese elements help determine how the reagent behaves in binding, stability, or quantitative measurements, and how closely it reflects biology in the chosen model system.\u003c\/p\u003e \u003ch2\u003eBiological background\u003c\/h2\u003e \u003cp\u003eRetinol-binding protein 4 (RBP4) is the primary plasma carrier for retinol (vitamin A alcohol) and commonly circulates in complex with transthyretin, which helps limit renal filtration. RBP4 is studied at the intersection of vitamin A transport, metabolism, and endocrine-like signaling.\u003c\/p\u003e\u003cp\u003eDelivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.\u003c\/p\u003e \u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eMetabolic research examining RBP4 as a context marker or mediator in insulin resistance and adipose signaling (RUO).\u003c\/li\u003e \u003cli\u003eVitamin A biology and nuclear receptor signaling studies where retinoid availability shapes transcriptional programs.\u003c\/li\u003e \u003cli\u003eSystems-level plasma proteomics where RBP4 abundance and complex formation can influence measurement and interpretation.\u003c\/li\u003e \u003c\/ul\u003e \u003ch2\u003eCommon research applications\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eControls\/standards for immunoassays measuring RBP4 in biological samples.\u003c\/li\u003e \u003cli\u003eLigand-binding studies focused on retinol transport and protein–protein complex formation with transthyretin.\u003c\/li\u003e \u003cli\u003eNutrient transport pathway studies integrating retinoid metabolism with cellular differentiation and immunity concepts.\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eUse changes in abundance, binding, or activity readouts as context-dependent signals. In many systems, differences may reflect regulation, compartment shifts, complex formation, or sample-matrix effects rather than a single direct mechanism.\u003c\/p\u003e \u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e \u003cul\u003e \u003cli\u003eLigand occupancy (retinol-bound vs apo) and complex formation can influence behavior and assay signals.\u003c\/li\u003e \u003cli\u003eRBP4 biology is tissue- and context-dependent; interpret changes alongside complementary metabolic markers.\u003c\/li\u003e \u003cli\u003eSample matrix effects can be substantial in plasma\/serum measurements; include appropriate controls.\u003c\/li\u003e \u003c\/ul\u003e \u003c!-- Sources (internal): - UniProt: https:\/\/www.uniprot.org\/uniprotkb?query=RBP4 retinol-binding protein 4 - NCBI Gene: https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=RBP4 retinol-binding protein 4 - PubMed: https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=RBP4 retinol-binding protein 4%20review --\u003e","brand":"CUSABIO TECHNOLOGY LLC","offers":[{"title":"1 g","offer_id":53052977054061,"sku":"CSB-NP070541h-1G","price":173335.0,"currency_code":"USD","in_stock":true},{"title":"100 mg","offer_id":53052977086829,"sku":"CSB-NP070541h-100MG","price":26665.0,"currency_code":"USD","in_stock":true},{"title":"10 mg","offer_id":53052977119597,"sku":"CSB-NP070541h-10MG","price":3335.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53052977152365,"sku":"CSB-NP070541h-1MG","price":630.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/CSB-NP070541h-SDS.jpg?v=1772166487","url":"https:\/\/www.ebiohippo.com\/products\/human-retinol-binding-protein-4-bhp10506059","provider":"BioHippo","version":"1.0","type":"link"}