{"product_id":"human-ribonucleoside-diphosphate-reductase-large-subunit-rrm1-elisa-kit-bhe13703002","title":"Human Ribonucleoside-diphosphate reductase large subunit (RRM1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Ribonucleoside-diphosphate reductase large subunit (RRM1) ELISA Kit has high sensitivity and excellent specificity for detection of Human RRM1. No significant cross-reactivity or interference between Human RRM1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eRRM1 encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338610172269,"sku":"KTE60786-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338753335661,"sku":"KTE60786-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338753368429,"sku":"KTE60786-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338753401197,"sku":"KTE60786-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60786.png?v=1778954693","url":"https:\/\/www.ebiohippo.com\/products\/human-ribonucleoside-diphosphate-reductase-large-subunit-rrm1-elisa-kit-bhe13703002","provider":"BioHippo","version":"1.0","type":"link"}