{"product_id":"human-sex-hormone-binding-globulin-bhp11006178","title":"Human Sex Hormone-Binding Globulin","description":"\u003cp\u003e\u003cstrong\u003eHuman Sex Hormone-Binding Globulin\u003c\/strong\u003e is supplied as a recombinant protein for in vitro research use.\u003c\/p\u003e\n\u003ch3\u003eBackground\u003c\/h3\u003e\n\u003cp\u003eSex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen\/estrogen balance, thyroid hormones, insulin and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone\/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.\u003c\/p\u003e\n\u003ch3\u003eProduct format\u003c\/h3\u003e\n\u003cp\u003eProvided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.\u003c\/p\u003e\n\u003ch3\u003eActivity \u0026amp; assay information\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Virus Test:\u003c\/strong\u003e FDA approved Plasma from each donor has been tested and found negative for antibodies to HIV-1 \u0026amp; 2, HCV, HBsAG, Parvovirus B19, HBc, HBV, HIV and Syphilis.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"ProSpec-Tany TechnoGene Ltd","offers":[{"title":"20 ug","offer_id":53038185054573,"sku":"pro-2757-20UG","price":330.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53038557102445,"sku":"pro-2757-100UG","price":700.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53038557135213,"sku":"pro-2757-1MG","price":2860.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Prospecbio-shbg-protein-PRO-2757.png?v=1782158399","url":"https:\/\/www.ebiohippo.com\/products\/human-sex-hormone-binding-globulin-bhp11006178","provider":"BioHippo","version":"1.0","type":"link"}