{"product_id":"human-ski-like-protein-skil-elisa-kit-bhe13702864","title":"Human Ski-like protein (SKIL) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Ski-like protein (SKIL) ELISA Kit has high sensitivity and excellent specificity for detection of Human SKIL. No significant cross-reactivity or interference between Human SKIL and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eThe mouse Sno gene expresses 2 isoforms, SnoN and SnoN2, that are different from each other in a location downstream of the site of alternative splicing previously described in the human SNO gene. SnoN2 is missing a 138-bp coding segment present in mouse SnoN and human SNON. TGFB induces activation and nuclear translocation of SMAD2, SMAD3, and SMAD4. SMAD3 causes degradation of SnoN, allowing a SMAD2\/SMAD4 complex to activate TGFB target genes. To initiate a negative feedback mechanism that permits a precise and timely regulation of TGFB signaling, TGFB also induces an increased expression of SnoN at a later stage, which in turn binds to SMAD heteromeric complexes and shuts off TGFB signaling.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338605912429,"sku":"KTE60648-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338739376493,"sku":"KTE60648-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338739409261,"sku":"KTE60648-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338739442029,"sku":"KTE60648-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60648.png?v=1778954679","url":"https:\/\/www.ebiohippo.com\/products\/human-ski-like-protein-skil-elisa-kit-bhe13702864","provider":"BioHippo","version":"1.0","type":"link"}