{"product_id":"human-sphingosine-kinase-1-spk1-elisa-kit-bhe13702745","title":"Human Sphingosine kinase 1 (SPK1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Sphingosine kinase 1 (SPK1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SPHK1. No significant cross-reactivity or interference between Human SPHK1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eSphingosine kinase 1 (SPK1) catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. SPK1, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for SPK1.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338602111341,"sku":"KTE60529-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338727711085,"sku":"KTE60529-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338727743853,"sku":"KTE60529-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338727776621,"sku":"KTE60529-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.ebiohippo.com\/products\/human-sphingosine-kinase-1-spk1-elisa-kit-bhe13702745","provider":"BioHippo","version":"1.0","type":"link"}