{"product_id":"human-synaptojanin-1-synj1-elisa-kit-bhe13702638","title":"Human Synaptojanin-1 (SYNJ1) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman Synaptojanin-1 (SYNJ1) ELISA Kit has high sensitivity and excellent specificity for detection of Human SYNJ1. No significant cross-reactivity or interference between Human SYNJ1 and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eSynaptojanin-1 is a phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) that has a role in clathrin-coated pit dynamics. The authors found that synaptojanin-170, an alternatively spliced isoform of SYNJ1, binds EPS15 , a clathrin coat-associated protein. Binding was mediated by the C-terminal region of synaptojanin-170, which contains 3 asparagine-proline-phenylalanine (NPF) repeats.\u003c\/p\u003e\u003cp\u003eThis motif had been found to be the core of the binding site for the EH domains of EPS15. These findings suggested that SYNJ1 can be recruited to clathrin-coated pits via a multiplicity of interactions.These Synj1-deficient mice exhibited neurologic defects and died shortly after birth.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338598572397,"sku":"KTE60421-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338716668269,"sku":"KTE60421-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338716701037,"sku":"KTE60421-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338716733805,"sku":"KTE60421-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60421.png?v=1778954661","url":"https:\/\/www.ebiohippo.com\/products\/human-synaptojanin-1-synj1-elisa-kit-bhe13702638","provider":"BioHippo","version":"1.0","type":"link"}