{"product_id":"human-tip41-like-protein-tiprl-elisa-kit-bhe13702538","title":"Human TIP41-like protein (TIPRL) ELISA Kit","description":"\u003cp\u003e\u003cb\u003eFeatures \u0026amp; Benefits\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eHuman TIP41-like protein (TIPRL) ELISA Kit has high sensitivity and excellent specificity for detection of Human TIPRL. No significant cross-reactivity or interference between Human TIPRL and analogues was observed.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e\u003c\/p\u003e\u003cp\u003eTIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A), PP4 , and PP6. TIP isoform-2 did not interact with PP2A, suggesting that the C terminus of TIP is important for PP2A binding. Incubation of PP2A with TIP, but not TIP isoform-2, resulted in dose-dependent inhibition of PP2A phosphatase activity. Cells in which TIP was depleted by small interfering RNA exhibited decreased phosphorylation of a 32-kD substrate of ATM\/ATR kinases.\u003c\/p\u003e\u003cp\u003eTIP is an inhibitory regulator of PP2A and that the TIP\/PP2A complex has a role within the ATM\/ATR signaling pathway controlling DNA replication and repair.The predicted protein contains 272 amino acids. Immunoblot analysis showed ubiquitous expression of a 33-kD TIP protein.\u003c\/p\u003e","brand":"Abbkine Scientific Co., Ltd.","offers":[{"title":"48 T","offer_id":53338595033453,"sku":"KTE60320-48T","price":339.0,"currency_code":"USD","in_stock":true},{"title":"96 T","offer_id":53338706903405,"sku":"KTE60320-96T","price":589.0,"currency_code":"USD","in_stock":true},{"title":"96 T×5","offer_id":53338706936173,"sku":"KTE60320-96TX5","price":2629.0,"currency_code":"USD","in_stock":true},{"title":"96 T×50","offer_id":53338706968941,"sku":"KTE60320-96TX50","price":24569.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KTE60320.png?v=1778954647","url":"https:\/\/www.ebiohippo.com\/products\/human-tip41-like-protein-tiprl-elisa-kit-bhe13702538","provider":"BioHippo","version":"1.0","type":"link"}