{"product_id":"iem-1921-bhb21300177","title":"IEM-1921","description":"\u003ch3\u003eProduct details\u003c\/h3\u003e \u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eChemical name:\u003c\/strong\u003e 1-phenylcyclohexan-1-amine\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlso known as:\u003c\/strong\u003e 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS number:\u003c\/strong\u003e 2201-24-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular formula:\u003c\/strong\u003e C12H17N\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcentration:\u003c\/strong\u003e 1-10 µM\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized Powder\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in DMSOUp to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReconstitution:\u003c\/strong\u003e Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg\/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eShipping:\u003c\/strong\u003e Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e NMDA receptor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSource:\u003c\/strong\u003e Synthetic\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eActivity:\u003c\/strong\u003e IEM-1921 is a selective NMDA receptor blocker and is a potent anticonvulsant 1-3.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative names:\u003c\/strong\u003e 1-Phenylcyclohexylamine, 4-Amino-4-phenylcyclohexane, PCA, 1-phenylcyclohexan-1-amine\u003c\/li\u003e\n\u003c\/ul\u003e \u003ch3\u003eScientific background\u003c\/h3\u003e \u003cp\u003eN-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in the central nervous system. Activation of NMDARs leads to cytosolic free intracellular calcium ([Ca2+]i) increase and for synaptic plasticity1.Abnormal activity of NMDA receptors is associated different neurodegenerative disorders such as Alzheimer's, Huntington's, Parkinson's disease and the etiology of epilepsy1.IEM-1921, also known as 1-phenylcyclohexylamine, is a selective blocker of NMDA receptors. In chronic experiments on Wistar and Krushinskii-Molodkina rats it was found that IEM-1921 (5mg\/kg) acts as anticonvulsant. IEM-1921 decreased the duration of convulsions by 82% and prevent neural abnormalities in the brain2-3.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eLead time:\u003c\/strong\u003e 1-2 Business Days\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eCountry of origin:\u003c\/strong\u003e Israel\/IL\u003c\/p\u003e \u003ch3\u003eApplications key\u003c\/h3\u003e \u003cp\u003eApplication key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eBioassay tested:\u003c\/strong\u003e Yes\u003c\/p\u003e","brand":"Alomone Labs","offers":[{"title":"10 mg \/ 1","offer_id":53249709080941,"sku":"I-180-10MG-1","price":147.0,"currency_code":"USD","in_stock":true},{"title":"25 mg \/ 1","offer_id":53311560909165,"sku":"I-180-25MG-1","price":292.0,"currency_code":"USD","in_stock":true},{"title":"5 mg \/ 1","offer_id":53311560941933,"sku":"I-180-5MG-1","price":92.0,"currency_code":"USD","in_stock":true},{"title":"50 mg \/ 1","offer_id":53311560974701,"sku":"I-180-50MG-1","price":466.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/I-180_str.png?v=1778544433","url":"https:\/\/www.ebiohippo.com\/products\/iem-1921-bhb21300177","provider":"BioHippo","version":"1.0","type":"link"}