{"product_id":"ifi44l-antibody-interferon-induced-protein-44-like-bha17135571","title":"IFI44L Antibody \/ Interferon-induced protein 44-like","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIFI44L Antibody \/ Interferon-induced protein 44-like is a anti-IFI44L Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human, Monkey, Mouse, Rat. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IFI44L\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIFI44L antibody detects Interferon-induced protein 44-like, an interferon-stimulated gene product that mediates antiviral defense and immune regulation. IFI44L is strongly induced by type I interferons and viral infection and contributes to suppression of viral replication and modulation of innate immune signaling. The IFI44L antibody is widely used in immunology and virology research to study interferon responses and antiviral mechanisms.\u003cbr\u003e\u003cbr\u003eIFI44L is encoded by the IFI44L gene on human chromosome 1p31.1. The protein is approximately 444 amino acids in length and localizes primarily in the cytoplasm, with some nuclear presence following interferon stimulation. Although its exact biochemical function remains under investigation, IFI44L is known to interact with cytoskeletal and RNA-binding proteins, influencing viral RNA recognition and replication.\u003cbr\u003e\u003cbr\u003eThe IFI44L antibody detects a 49 kilodalton protein by western blot and shows diffuse cytoplasmic staining under immunofluorescence microscopy. IFI44L expression is tightly correlated with type I interferon activity, serving as a biomarker for systemic lupus erythematosus and other interferonopathies. It enhances the antiviral state by restricting replication of RNA viruses such as influenza, hepatitis C, and coronaviruses through modulation of double-stranded RNA signaling and translation inhibition.\u003cbr\u003e\u003cbr\u003eIn addition to antiviral roles, IFI44L modulates immune cell differentiation and inflammation. Elevated IFI44L levels contribute to interferon signature profiles observed in autoimmune diseases, whereas reduced expression can impair viral clearance. Epigenetic regulation of the IFI44L promoter influences susceptibility to immune dysregulation and chronic infection.\u003cbr\u003e\u003cbr\u003eBecause IFI44L serves as a downstream effector of interferon signaling, it provides a useful marker for evaluating innate immune activation and viral suppression.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IFI44L - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IFI44L - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IFI44L - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IFI44L - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IFI44L+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047297442157,"sku":"FY12668","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_fd046e11-21cf-47a0-83ee-869f8ffc15be.jpg?v=1782237031","url":"https:\/\/www.ebiohippo.com\/products\/ifi44l-antibody-interferon-induced-protein-44-like-bha17135571","provider":"BioHippo","version":"1.0","type":"link"}