{"product_id":"igf1r-antibody-insulin-like-growth-factor-1-receptor-bha17135267","title":"IGF1R Antibody \/ Insulin-like growth factor 1 receptor","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIGF1R Antibody \/ Insulin-like growth factor 1 receptor is a anti-IGF1R Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IGF1R\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eThe IGF1R antibody targets Insulin-like growth factor 1 receptor, a transmembrane tyrosine kinase receptor encoded by the IGF1R gene. This receptor mediates the biological effects of insulin-like growth factors IGF1 and IGF2, regulating growth, differentiation, and survival in many cell types. Insulin-like growth factor 1 receptor activates key signaling cascades, including the PI3K-AKT and MAPK pathways, that promote cell proliferation and metabolism. The IGF1R antibody enables researchers to examine receptor expression, signaling activation, and involvement in normal physiology and disease.\u003cbr\u003e\u003cbr\u003eInsulin-like growth factor 1 receptor is synthesized as a single-chain precursor that is cleaved into alpha and beta subunits, forming a disulfide-linked heterotetramer. The extracellular alpha subunits bind ligand, while the transmembrane beta subunits contain intrinsic tyrosine kinase domains responsible for signal transduction. The IGF1R antibody allows detection of both full-length and processed receptor forms, supporting detailed analysis of receptor biosynthesis and activation states.\u003cbr\u003e\u003cbr\u003eIGF1R signaling is essential for embryonic growth, tissue regeneration, and metabolic control. Activation of the receptor stimulates glucose uptake, protein synthesis, and cell survival pathways, maintaining anabolic balance. Dysregulation of Insulin-like growth factor 1 receptor has been linked to cancer, diabetes, and aging-related pathologies. The IGF1R antibody provides a valuable tool for monitoring these changes and understanding how altered receptor signaling drives disease progression. In cancer research, IGF1R overexpression promotes tumor cell proliferation, invasion, and resistance to apoptosis, making it a key target for therapeutic intervention.\u003cbr\u003e\u003cbr\u003eIn developmental and metabolic studies, the IGF1R antibody helps characterize how ligand-receptor interactions influence growth hormone signaling and nutrient sensing. Immunohistochemistry and immunofluorescence using this antibody reveal receptor localization at the plasma membrane and endosomal compartments, reflecting active signaling dynamics. In addition, phosphorylation-specific variants of the IGF1R antibody can distinguish active receptor states, complementing this general reagent for total protein analysis.\u003cbr\u003e\u003cbr\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IGF1R - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IGF1R - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IGF1R - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IGF1R - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IGF1R+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047288365421,"sku":"FY12364","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c5c15300-9f3e-4b5c-8c36-b99ed3ddf665.jpg?v=1782236993","url":"https:\/\/www.ebiohippo.com\/products\/igf1r-antibody-insulin-like-growth-factor-1-receptor-bha17135267","provider":"BioHippo","version":"1.0","type":"link"}