{"product_id":"igr-1-cell-bhc11100071","title":"IGR-1 cell","description":"The IGR-1 cell line is derived from a human malignant melanoma, making it a valuable model for studying the pathophysiology of melanoma and testing anti-cancer therapies. These cells are epithelial in nature and exhibit characteristics typical of aggressive melanoma, including rapid proliferation and the ability to form colonies in soft agar, a hallmark of oncogenic transformation. The IGR-1 cell line is particularly useful in research focused on understanding the molecular mechanisms driving melanoma progression, as well as in the development and testing of targeted therapies and immunotherapies.\n\nIGR-1 cells harbor mutations common in melanoma, including alterations in the MAPK\/ERK pathway, which is often dysregulated in this cancer type. These mutations contribute to the cell line's ability to proliferate uncontrollably and resist apoptosis. Researchers utilize IGR-1 cells to investigate the effects of various inhibitors on this signaling pathway, providing insights into potential therapeutic strategies. Additionally, the cell line's expression of melanoma-associated antigens makes it suitable for studying immune responses against melanoma, including the development of novel immunotherapeutic approaches.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100071\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212510061,"sku":"300219","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/IGR-1_20P1_2020x01_20100925_ch00_1920x1920_be5d89b1-c702-4743-bdd2-1de7cb07e754.png?v=1769069113","url":"https:\/\/www.ebiohippo.com\/products\/igr-1-cell-bhc11100071","provider":"BioHippo","version":"1.0","type":"link"}