{"product_id":"il15-antibody-interleukin-15-bha17135351","title":"IL15 Antibody \/ Interleukin 15","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIL15 Antibody \/ Interleukin 15 is a anti-IL15 Rabbit antibody Recombinant Rabbit Monoclonal clone 31I07 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL15\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31I07, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIL15 antibody detects interleukin 15, a pleiotropic cytokine encoded by the IL15 gene. IL15 belongs to the four alpha helix bundle cytokine family and shares functional similarities with interleukin 2. It plays a crucial role in the activation and survival of natural killer cells and memory CD8 T cells. IL15 signals through a receptor complex composed of IL15R alpha, IL2R beta, and the common gamma chain. Through these interactions, IL15 contributes to immune homeostasis, antiviral defense, and antitumor activity.\u003cbr\u003e\u003cbr\u003eIL15 antibody is widely used in immunology, cancer immunotherapy, and infectious disease research. IL15 stimulates proliferation and cytotoxicity of natural killer and CD8 T cells, making it a key cytokine in immune defense. In cancer research, IL15 is studied for its ability to boost antitumor immune responses, and recombinant IL15 is under evaluation in clinical trials as an immunotherapeutic agent. By detecting IL15 expression, researchers can monitor immune activity and evaluate therapeutic strategies.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, flow cytometry, and ELISA. In western blot assays, IL15 antibody identifies protein bands corresponding to the cytokine. Immunohistochemistry localizes IL15 expression within tissues, while immunofluorescence demonstrates cytokine production in immune cell subsets. Flow cytometry enables quantitative detection of IL15 in activated lymphocytes, and ELISA applications support measurement of secreted IL15 in serum or culture media.\u003cbr\u003e\u003cbr\u003eIL15 plays roles in autoimmune disease, chronic inflammation, and transplant rejection. Elevated levels contribute to pathological immune activation in conditions such as rheumatoid arthritis, psoriasis, and celiac disease. Conversely, inadequate IL15 signaling impairs immune defense against viral infections. By applying IL15 antibody, researchers can investigate both protective and pathogenic functions of this cytokine.\u003cbr\u003e\u003cbr\u003eIn addition to its role in adaptive immunity, IL15 regulates innate lymphoid cell function and promotes tissue specific immune surveillance. It is particularly important in mucosal immunity, where it supports barrier protection against pathogens. IL15 antibody therefore provides a versatile tool for basic and translational immunology.\u003cbr\u003e\u003cbr\u003eIL15 antibody provided by\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL15 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL15 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL15 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL15 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL15+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047289020781,"sku":"FY12448","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_d5d15c3c-6cc7-4212-b14b-e55ecfc8e7f9.jpg?v=1772019289","url":"https:\/\/www.ebiohippo.com\/products\/il15-antibody-interleukin-15-bha17135351","provider":"BioHippo","version":"1.0","type":"link"}