{"product_id":"il18bp-antibody-il18-binding-protein-bha17135622","title":"IL18BP Antibody \/ IL18 binding protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIL18BP Antibody \/ IL18 binding protein is a anti-IL18BP Rabbit antibody Recombinant Rabbit Monoclonal clone 31I00 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL18BP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31I00, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIL18BP antibody detects interleukin 18 binding protein, encoded by the IL18BP gene. This secreted glycoprotein functions as a natural inhibitor of interleukin 18, a proinflammatory cytokine. Alternate names include IL18BPa, IL18BPb, and IL18BPc, reflecting the multiple isoforms generated by alternative splicing. IL18BP neutralizes IL18 by binding with high affinity, preventing its interaction with the IL18 receptor and subsequent activation of NF kappa B and interferon gamma pathways.\u003cbr\u003e\u003cbr\u003eIL18BP antibody is widely applied in immunology, inflammation research, and translational medicine. By detecting IL18BP, researchers can investigate how immune regulation balances inflammatory cytokine activity. Overexpression of IL18BP provides protection from excessive inflammation, while deficiency or altered expression contributes to autoimmune disorders and infectious disease susceptibility.\u003cbr\u003e\u003cbr\u003e ELISA detects IL18BP in serum and culture supernatants, while western blotting identifies isoform expression. Immunohistochemistry maps IL18BP production in tissues undergoing immune activation. These methods make IL18BP antibody useful for evaluating cytokine regulation in health and disease.\u003cbr\u003e\u003cbr\u003eIL18BP has therapeutic potential as a biologic agent. Recombinant IL18BP has been developed to treat inflammatory diseases such as adult onset Still disease and hemophagocytic lymphohistiocytosis. By applying IL18BP antibody, researchers can monitor therapeutic levels and investigate how modulation of IL18 signaling influences disease outcomes.\u003cbr\u003e\u003cbr\u003eIL18BP antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL18BP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL18BP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL18BP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL18BP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL18BP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047297245549,"sku":"FY12719","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c29f79ef-0b63-49b7-8638-185fe529f7dc.jpg?v=1772019333","url":"https:\/\/www.ebiohippo.com\/products\/il18bp-antibody-il18-binding-protein-bha17135622","provider":"BioHippo","version":"1.0","type":"link"}