{"product_id":"il2-antibody-interleukin-2-bha17135460","title":"IL2 Antibody \/ Interleukin 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIL2 Antibody \/ Interleukin 2 is a anti-IL2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIL2 antibody detects Interleukin-2, a cytokine essential for lymphocyte proliferation, immune tolerance, and cytotoxic activation. IL2 was one of the first cytokines to be molecularly cloned and remains a central molecule in immunology due to its dual role in promoting effector responses and maintaining regulatory T cell (Treg) homeostasis. The IL2 antibody is widely used in immunology and cancer research to investigate T-cell activation, cytokine signaling, and immune regulation.\u003cbr\u003e\u003cbr\u003eIL2 is encoded by the IL2 gene on human chromosome 4q27. The protein is produced primarily by activated CD4+ T cells as a 153-amino acid precursor, which is processed to a 15.5 kilodalton mature secreted cytokine. IL2 binds with high affinity to the heterotrimeric IL2 receptor complex (IL2Ralpha\/CD25, IL2Rbeta\/CD122, and gammac\/CD132), triggering JAK1\/3-mediated phosphorylation of STAT5 and subsequent transcription of proliferation and survival genes.\u003cbr\u003e\u003cbr\u003eThe IL2 antibody detects secreted and intracellular IL2 by western blot or immunoassay, and shows cytoplasmic and perinuclear staining in activated lymphocytes. IL2 drives clonal expansion of T and NK cells, enhances cytotoxicity, and induces differentiation of regulatory T cells to maintain immune balance. Dysregulation of IL2 signaling leads to immune deficiency or autoimmunity, depending on whether its production or receptor function is impaired.\u003cbr\u003e\u003cbr\u003eClinically, IL2 forms the basis for several immunotherapeutic strategies, including recombinant IL2 (aldesleukin) for metastatic melanoma and renal carcinoma. It also serves as a biomarker for T-cell activation in immunomonitoring assays. Genetic polymorphisms in IL2 or its receptor subunits have been associated with autoimmune diseases such as type 1 diabetes, rheumatoid arthritis, and multiple sclerosis.\u003cbr\u003e\u003cbr\u003eAs a key cytokine in immune communication, IL2 bridges innate and adaptive responses, coordinating activation, tolerance, and memory formation.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047292526957,"sku":"FY12557","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_390615f5-c0b6-4da3-a854-060f60df07bb.jpg?v=1782237025","url":"https:\/\/www.ebiohippo.com\/products\/il2-antibody-interleukin-2-bha17135460","provider":"BioHippo","version":"1.0","type":"link"}