{"product_id":"il22-antibody-interleukin-22-bha17135254","title":"IL22 Antibody \/ Interleukin 22","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIL22 Antibody \/ Interleukin 22 is a anti-IL22 Rabbit antibody Recombinant Rabbit Monoclonal clone 31I09 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL22\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 31I09, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIL22 antibody is designed to detect interleukin 22, a member of the IL10 cytokine family. IL22 is produced by activated T helper 17 cells, innate lymphoid cells, and other immune subsets. It acts mainly on non hematopoietic cells such as epithelial cells, hepatocytes, and keratinocytes. IL22 promotes antimicrobial defense, tissue repair, and inflammatory responses by activating the JAK STAT signaling pathway. Through its effects on barrier tissues, IL22 plays an important role in maintaining host defense and tissue integrity.\u003cbr\u003e\u003cbr\u003eIL22 antibody is commonly used in immunology, infectious disease, and cancer research. By detecting IL22 expression, researchers can explore how cytokine networks regulate immune responses at mucosal surfaces and within tissues. IL22 is known to induce antimicrobial peptide production in epithelial cells, enhancing resistance to bacterial and fungal pathogens. It also contributes to tissue regeneration following injury, linking immunity with repair mechanisms.\u003cbr\u003e\u003cbr\u003eThe antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In flow cytometric assays, IL22 antibody enables quantitative analysis of cytokine production by T cells or innate lymphoid cells. Immunohistochemistry localizes IL22 expression within tissues, highlighting immune epithelial interactions. Immunofluorescence allows visualization of cytokine production at the cellular level, while western blotting confirms protein expression in experimental samples. These applications make IL22 antibody a versatile reagent for diverse research programs.\u003cbr\u003e\u003cbr\u003eIn disease contexts, IL22 has a dual role. It provides protective immunity in infections and promotes wound healing, but excessive or chronic IL22 signaling contributes to inflammatory diseases such as psoriasis, colitis, and arthritis. Monitoring IL22 with specific antibodies helps define its protective versus pathogenic roles. In oncology, IL22 has been implicated in promoting tumor growth by enhancing cell survival, angiogenesis, and invasion in certain cancers. These opposing effects underscore the importance of precise measurement using reliable reagents.\u003cbr\u003e\u003cbr\u003eIL22 antibody is also valuable for therapeutic research. Neutralizing IL22 signaling may help treat autoimmune or inflammatory diseases, while enhancing IL22 activity could be beneficial for boosting host defense and tissue repair. Antibody based studies allow scientists to evaluate these strategies by accurately tracking IL22 levels in preclinical and translational models.\u003cbr\u003e\u003cbr\u003eIL22 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL22 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL22 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL22 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL22 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL22+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047285416301,"sku":"FY12351","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_c9ca60e8-1c19-40eb-bcaf-78f8b0ffcad9.jpg?v=1772019289","url":"https:\/\/www.ebiohippo.com\/products\/il22-antibody-interleukin-22-bha17135254","provider":"BioHippo","version":"1.0","type":"link"}