{"product_id":"il7ra-antibody-interleukin-7-receptor-alpha-cd127-bha17136308","title":"IL7RA Antibody \/ Interleukin-7 receptor alpha \/ CD127","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIL7RA Antibody \/ Interleukin-7 receptor alpha \/ CD127 is a anti-IL7RA Rabbit antibody Recombinant Rabbit Monoclonal clone 22I71 supplied in Purified format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat. Reported localization: Cell membrane, secreted.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IL7RA\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 22I71, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Purified\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eInterleukin-7 receptor alpha (IL7RA) is a type I transmembrane glycoprotein that forms part of the receptor complex for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP). It plays a crucial role in lymphocyte development, survival, and homeostasis, particularly in T-cell and B-cell biology.    \u003cp\u003eGenetic variations in IL7RA have been associated with susceptibility to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, as well as immune deficiency disorders. IL7RA signaling regulates lymphocyte proliferation, differentiation, and maintenance, making it a valuable focus for immunological and therapeutic research. \u003c\/p\u003e\n\u003cp\u003eUsing a high-quality IL7RA antibody enables accurate detection of the protein in applications including western blot, immunohistochemistry, and flow cytometry. An IL7RA antibody from\u003c\/p\u003e\n\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IL7RA - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IL7RA - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IL7RA - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IL7RA - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IL7RA+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047324672365,"sku":"RQ8889","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_b7cd95f9-bc58-4b54-b931-359e48d1d82a.jpg?v=1772019440","url":"https:\/\/www.ebiohippo.com\/products\/il7ra-antibody-interleukin-7-receptor-alpha-cd127-bha17136308","provider":"BioHippo","version":"1.0","type":"link"}