{"product_id":"immortalized-hk-fdc-cell-bhc11101667","title":"Immortalized HK\/FDC cell","description":"The immortalized HK\/FDC cell line is a genetically stabilized derivative of the original HK follicular dendritic cell-like cells, retaining key phenotypic and functional characteristics while enabling extended propagation without the senescence-associated limitations of the parental culture. Immortalization was achieved through the introduction of defined genetic elements that bypass replicative arrest, facilitating consistent long-term studies of germinal center biology and FDC–B cell interactions. Immortalized HK\/FDC cells maintain the capacity to bind and co-stimulate germinal center B cells, promote their survival, and enhance their proliferation in the presence of signals such as anti-IgM or CD40 ligation. Importantly, they continue to express adhesion molecules and costimulatory factors characteristic of FDCs, including VCAM-1 and ICAM-1, and secrete soluble mediators that mimic the microenvironmental support provided by native FDCs. These properties make the immortalized HK\/FDC line a robust and reproducible model for dissecting the cellular and molecular mechanisms governing B cell maturation, affinity selection, and survival within the germinal center.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101667\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212608365,"sku":"300205","price":1500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HK_20888_20WaKo_20DAY3_20P1_2020X01_20311025_Overlay_1920x1920_36cc1117-8d29-481a-883b-22ff32e4e712.png?v=1769069115","url":"https:\/\/www.ebiohippo.com\/products\/immortalized-hk-fdc-cell-bhc11101667","provider":"BioHippo","version":"1.0","type":"link"}