{"product_id":"inmt-antibody-temt-bha17135618","title":"INMT Antibody \/ TEMT","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eINMT Antibody \/ TEMT is a anti-INMT Rabbit antibody Recombinant Rabbit Monoclonal clone 29I89 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e INMT\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29I89, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eINMT antibody detects indolethylamine N methyltransferase, also known as TEMT, encoded by the INMT gene. INMT is a cytosolic enzyme that catalyzes the N methylation of tryptamine and other indolethylamines, producing N N dimethyltryptamine and related metabolites. This activity places INMT in pathways regulating biogenic amine metabolism, neurotransmitter balance, and endogenous hallucinogen production. INMT is expressed in liver, lung, brain, and peripheral tissues, suggesting roles in both metabolic clearance and neuroregulation.\u003cbr\u003e\u003cbr\u003eINMT antibody is widely applied in neurobiology, pharmacology, and metabolism research. INMT contributes to serotonin and tryptamine metabolism and has been proposed as the enzyme responsible for biosynthesis of endogenous dimethyltryptamine in mammals. By detecting INMT, researchers can examine its distribution, activity, and regulation in diverse tissues.\u003cbr\u003e\u003cbr\u003e Western blotting with INMT antibody detects enzyme expression in liver and brain samples. Immunohistochemistry maps expression in neuronal and peripheral tissues, while immunofluorescence highlights cytoplasmic localization within cells. These approaches provide powerful tools for characterizing INMT biology.\u003cbr\u003e\u003cbr\u003eINMT has clinical and pharmacological significance. Altered expression has been linked to pulmonary hypertension, schizophrenia, and other neuropsychiatric conditions. Genetic polymorphisms in INMT influence enzyme activity and metabolic profiles. By applying INMT antibody, scientists can explore how changes in tryptamine metabolism contribute to disease and therapeutic response.\u003cbr\u003e\u003cbr\u003eINMT also participates in xenobiotic metabolism by methylating exogenous compounds. Its role in detoxification pathways expands its relevance to pharmacology and toxicology. INMT antibody supports studies into how methyltransferases regulate chemical balance in the body.\u003cbr\u003e\u003cbr\u003eResearch continues to evaluate INMT in neurological function, where dimethyltryptamine has been implicated in altered states of consciousness and potential therapeutic applications. Investigating INMT expression with antibody based methods provides insights into both fundamental biology and emerging areas of translational research.\u003cbr\u003e\u003cbr\u003eINMT antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=INMT - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=INMT - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=INMT - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/INMT - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=INMT+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047297114477,"sku":"FY12715","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_e1af8e85-32de-44c9-9151-a210231533ff.jpg?v=1772019330","url":"https:\/\/www.ebiohippo.com\/products\/inmt-antibody-temt-bha17135618","provider":"BioHippo","version":"1.0","type":"link"}