{"product_id":"insm2-antibody-insulinoma-associated-protein-2-bha17135943","title":"INSM2 Antibody \/ Insulinoma-associated protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eINSM2 Antibody \/ Insulinoma-associated protein 2 is a anti-INSM2 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e INSM2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eINSM2 antibody detects Insulinoma-associated protein 2, a zinc finger transcriptional regulator implicated in neuroendocrine differentiation, metabolic regulation, and pancreatic development. The UniProt recommended name is Insulinoma-associated protein 2 (INSM2). This nuclear protein belongs to the INSM family of transcriptional repressors, which also includes INSM1, and contributes to neuronal and endocrine lineage specification through transcriptional control of differentiation-related genes.\u003cbr\u003e\u003cbr\u003eFunctionally, INSM2 antibody identifies a 566-amino-acid nuclear protein characterized by two C2H2-type zinc finger domains responsible for DNA binding. INSM2 functions primarily as a transcriptional repressor by interacting with chromatin modifiers such as histone deacetylases (HDACs) and corepressors, leading to silencing of target genes involved in progenitor proliferation and differentiation timing. Its expression is enriched in neuroendocrine tissues, including pancreatic islets, hypothalamus, and pituitary gland.\u003cbr\u003e\u003cbr\u003eThe INSM2 gene is located on chromosome 14q32.33 and is transcriptionally regulated by developmental factors that control endocrine and neural specification. During embryogenesis, INSM2 expression marks neuroendocrine progenitors, where it modulates hormone biosynthesis and secretory machinery gene networks. In pancreatic beta cells, INSM2 contributes to insulin production and glucose homeostasis by regulating transcription of genes linked to secretion and vesicle trafficking.\u003cbr\u003e\u003cbr\u003eIn the central nervous system, INSM2 plays roles in hypothalamic and pituitary differentiation, influencing neuroendocrine circuit formation. Its function overlaps with, but is distinct from, INSM1, with both cooperating to maintain endocrine identity and suppress premature differentiation. In metabolic tissues, INSM2 has been implicated in lipid and glucose metabolism, linking endocrine signaling to energy balance. Emerging studies also associate INSM2 with neuroendocrine tumors, where its upregulation may reflect differentiation status and secretory activity.\u003cbr\u003e\u003cbr\u003eINSM2 antibody is widely used in developmental biology, endocrinology, and neurobiology research. It is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect INSM2 expression in neural and endocrine tissues. This antibody supports studies of transcriptional regulation, endocrine cell differentiation, and metabolic gene networks. In translational research, INSM2 serves as a marker for neuroendocrine lineage commitment and tumor differentiation.\u003cbr\u003e\u003cbr\u003eStructurally, INSM2 contains zinc finger DNA-binding motifs and nuclear localization signals that enable chromatin association. It functions within transcriptional repressor complexes containing HDAC1\/2 and REST corepressors.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=INSM2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=INSM2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=INSM2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/INSM2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=INSM2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047310516589,"sku":"FY13041","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5fa75a32-c6f9-4f2d-a480-3c5fbfaeb3ce.jpg?v=1782237068","url":"https:\/\/www.ebiohippo.com\/products\/insm2-antibody-insulinoma-associated-protein-2-bha17135943","provider":"BioHippo","version":"1.0","type":"link"}