{"product_id":"ipilimumab-biosimilar-research-grade-bha18300166","title":"Ipilimumab Biosimilar - Research Grade","description":"\u003cstyle\u003e\n.bhp-desc{font-size:16px;color:#1a1a1a;line-height:1.7}\n.bhp-desc h2{font-size:18px;font-weight:700;color:#003366;margin:24px 0 10px;padding-bottom:6px;border-bottom:2px solid #003366}\n.bhp-desc p{margin:0 0 12px}\n.bhp-desc .bhp-spec-table{width:100%;border-collapse:collapse;margin:12px 0 18px}\n.bhp-desc .bhp-spec-table th{width:36%;text-align:left;padding:8px 12px;background:#e8f0fb;color:#003366;font-weight:600;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-spec-table td{padding:8px 12px;vertical-align:top;border:1px solid #ccd9f0}\n.bhp-desc .bhp-qc-badge{display:inline-block;background:#e6f4ea;color:#1a7a3c;border:1px solid #a8d5b5;border-radius:4px;padding:6px 14px;font-size:14px;font-weight:600}\n.bhp-desc .bhp-warning-box{background:#fff8e6;border-left:4px solid #e6a817;padding:10px 14px;margin:10px 0 14px;border-radius:0 4px 4px 0}\n.bhp-desc .bhp-cat-pill{display:inline-block;background:#003366;color:#fff;border-radius:20px;padding:3px 12px;font-size:13px;margin-bottom:10px}\n\u003c\/style\u003e\n\u003cdiv class=\"bhp-desc\"\u003e\n  \u003cspan class=\"bhp-cat-pill\"\u003eHuman monoclonal antibody\u003c\/span\u003e\n\n  \u003ch2\u003eProduct Overview\u003c\/h2\u003e\n  \u003cp\u003eThis is a research-grade recombinant antibody that reproduces the antigen-binding specificity of the reference therapeutic \u003cstrong\u003eIpilimumab\u003c\/strong\u003e. Like the reference molecule, it binds CTLA-4 and blocks its interaction with CD80\/CD86, enhancing T-cell activation. It is intended for \u003cem\u003ein vitro\u003c\/em\u003e research use as a binding reagent, functional (blocking\/neutralizing) tool, and as a positive control or reference standard in bioanalytical assays.\u003c\/p\u003e\n  \u003cp\u003eThis product carries the same variable-region specificity as Ipilimumab and therefore targets \u003cstrong\u003eCTLA-4 (CD152)\u003c\/strong\u003e. It is a research reagent and is not the licensed therapeutic product.\u003c\/p\u003e\n\n  \u003ch2\u003eTarget \u0026amp; Mechanism\u003c\/h2\u003e\n  \u003cp\u003eTarget antigen: \u003cstrong\u003eCTLA-4 (CD152)\u003c\/strong\u003e. The molecule binds CTLA-4 and blocks its interaction with CD80\/CD86, enhancing T-cell activation.\u003c\/p\u003e\n\n  \u003ch2\u003eResearch Applications\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eApplication\u003c\/th\u003e\n\u003cth\u003eNotes\u003c\/th\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003eELISA (antigen binding)\u003c\/td\u003e\n\u003ctd\u003eUse as a binding reagent against CTLA-4 (CD152); suitable as a capture\/detection antibody and as an assay control.\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003eLigand blocking \/ neutralization\u003c\/td\u003e\n\u003ctd\u003eFunctional blocking of CTLA-4 (CD152) in biochemical or cell-based assays.\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003eBiophysics (SPR \/ BLI)\u003c\/td\u003e\n\u003ctd\u003eKinetic and affinity characterization of binding to CTLA-4 (CD152).\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003eFlow cytometry\u003c\/td\u003e\n\u003ctd\u003eDetection of cell-surface CTLA-4 (CD152) on relevant cell types.\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003ctd\u003ePK \/ ADA assay control\u003c\/td\u003e\n\u003ctd\u003ePositive control or reference standard in pharmacokinetic (drug-level) and anti-drug-antibody (immunogenicity) assays for Ipilimumab.\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003ch2\u003eSpecifications\u003c\/h2\u003e\n  \u003ctable class=\"bhp-spec-table\"\u003e\n    \u003ctr\u003e\n\u003cth\u003eReference product\u003c\/th\u003e\n\u003ctd\u003eIpilimumab\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eMolecular format\u003c\/th\u003e\n\u003ctd\u003eHuman monoclonal antibody\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eTarget antigen\u003c\/th\u003e\n\u003ctd\u003eCTLA-4 (CD152)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eIsotype \/ class\u003c\/th\u003e\n\u003ctd\u003eIgG1κ\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eExpression\u003c\/th\u003e\n\u003ctd\u003eRecombinant, mammalian cell expression (see datasheet for lot details)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003ePurity \/ concentration \/ endotoxin\u003c\/th\u003e\n\u003ctd\u003eLot-specific — stated on the Certificate of Analysis\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eFormulation\u003c\/th\u003e\n\u003ctd\u003eSupplied in PBS, pH 7.0 (see datasheet)\u003c\/td\u003e\n\u003c\/tr\u003e\n    \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003e-20°C long term; avoid repeated freeze–thaw cycles\u003c\/td\u003e\n\u003c\/tr\u003e\n  \u003c\/table\u003e\n\n  \u003ch2\u003eValidation \u0026amp; QC\u003c\/h2\u003e\n  \u003cp\u003e\u003cspan class=\"bhp-qc-badge\"\u003eCertificate of Analysis supplied per lot\u003c\/span\u003e\u003c\/p\u003e\n  \u003cp\u003eTypical release testing includes identity\/purity by SDS-PAGE and confirmation of CTLA-4 (CD152) binding by ELISA or SPR\/BLI. Full validation data and the product datasheet are available on request.\u003c\/p\u003e\n\n  \u003ch2\u003eSafety \u0026amp; Handling\u003c\/h2\u003e\n  \u003cdiv class=\"bhp-warning-box\"\u003e\n    \u003cp\u003e\u003cstrong\u003eFor Research Use Only (RUO).\u003c\/strong\u003e Not for diagnostic, therapeutic, or human\/animal \u003cem\u003ein vivo\u003c\/em\u003e use. Handle in accordance with good laboratory practice.\u003c\/p\u003e\n  \u003c\/div\u003e\n\n  \u003ch2\u003eRelated Products\u003c\/h2\u003e\n  \u003cp\u003ePair with the matching anti-idiotypic antibody and the Ipilimumab drug-level (PK) and anti-drug-antibody (ADA) ELISA kits for a complete bioanalytical workflow. Explore related antibodies, kits and reagents at \u003ca href=\"https:\/\/www.ebiohippo.com\" target=\"_blank\"\u003eBioHippo\u003c\/a\u003e.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"AffinityImmuno Inc.","offers":[{"title":"500 ug","offer_id":53327961882989,"sku":"ab-131-ipilimumab","price":305.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/AffinityImmuno-Product-Antbodies-4_6c85ec3e-60ca-4851-b6f8-72c9f77198a7.jpg?v=1778728456","url":"https:\/\/www.ebiohippo.com\/products\/ipilimumab-biosimilar-research-grade-bha18300166","provider":"BioHippo","version":"1.0","type":"link"}