{"product_id":"iqgap2-antibody-iq-motif-containing-gtpase-activating-protein-2-bha17135921","title":"IQGAP2 Antibody \/ IQ motif containing GTPase activating protein 2","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIQGAP2 Antibody \/ IQ motif containing GTPase activating protein 2 is a anti-IQGAP2 Rabbit antibody Recombinant Rabbit Monoclonal clone 29I69 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse. Reported localization: Cytoplasm.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IQGAP2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29I69, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIQGAP2 antibody detects IQ motif containing GTPase activating protein 2, encoded by the IQGAP2 gene. IQ motif containing GTPase activating protein 2 belongs to the IQGAP family of scaffolding proteins that interact with Rho family GTPases, actin filaments, and signaling molecules. It plays an important role in cytoskeletal organization, cell adhesion, and intracellular signaling. IQGAP2 antibody provides researchers with a means to study its contribution to cytoskeletal regulation, liver physiology, and cancer biology.\u003cbr\u003e\u003cbr\u003eUnlike its homolog IQGAP1, which promotes oncogenic signaling, IQGAP2 functions primarily as a tumor suppressor. Research with IQGAP2 antibody has shown that loss of IQGAP2 expression is frequent in hepatocellular carcinoma and gastric cancer, where it contributes to uncontrolled proliferation and reduced cell adhesion. By interacting with Rho family GTPases, IQGAP2 regulates actin dynamics and stabilizes adherens junctions, helping maintain epithelial integrity. Loss of this regulation increases motility and invasion, linking IQGAP2 deficiency to metastatic progression.\u003cbr\u003e\u003cbr\u003eIQGAP2 is also important in liver biology. Studies using IQGAP2 antibody have demonstrated that knockout mice develop spontaneous hepatocellular carcinoma, confirming its tumor suppressor role. In normal liver tissue, IQGAP2 interacts with beta catenin and other signaling molecules to regulate hepatocyte growth and polarity. Dysregulation of this protein contributes to abnormal signaling through pathways such as Wnt and PI3K AKT, reinforcing its significance in liver disease and cancer.\u003cbr\u003e\u003cbr\u003eBeyond the liver, IQGAP2 contributes to immune regulation and cytoskeletal remodeling in other tissues. It has been implicated in platelet activation, immune synapse formation, and gastric mucosal stability. Research with IQGAP2 antibody continues to expand understanding of its roles in diverse systems. Importantly, reduced expression of IQGAP2 in tumors is associated with poor prognosis, making it a potential biomarker for patient stratification.\u003cbr\u003e\u003cbr\u003eIQGAP2 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects expression in liver and epithelial cell lines, while immunohistochemistry highlights its localization at cell junctions in tissues. Immunofluorescence reveals its colocalization with actin and signaling molecules, providing insights into cytoskeletal regulation. These methods ensure that IQGAP2 antibody is valuable for both fundamental and translational research.\u003cbr\u003e\u003cbr\u003eBy providing validated IQGAP2 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IQGAP2 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IQGAP2 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IQGAP2 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IQGAP2 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IQGAP2+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047309205869,"sku":"FY13019","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_3f74d5b2-6ae1-4ae4-812c-bf277d3ead95.jpg?v=1782237086","url":"https:\/\/www.ebiohippo.com\/products\/iqgap2-antibody-iq-motif-containing-gtpase-activating-protein-2-bha17135921","provider":"BioHippo","version":"1.0","type":"link"}