{"product_id":"irgq-antibody-immunity-related-gtpase-family-q-protein-bha17136049","title":"IRGQ Antibody \/ Immunity-related GTPase family Q protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIRGQ Antibody \/ Immunity-related GTPase family Q protein is a anti-IRGQ Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IRGQ\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIRGQ antibody detects Immunity-related GTPase family Q protein, a dynamin-like GTPase that participates in vesicular trafficking, membrane remodeling, and host defense mechanisms. The UniProt recommended name is Immunity-related GTPase family Q protein (IRGQ). This enzyme belongs to the immunity-related GTPase (IRG) family, known for regulating intracellular pathogen resistance and organelle dynamics in immune cells.\u003cbr\u003e\u003cbr\u003eFunctionally, IRGQ antibody identifies a 409-amino-acid GTP-binding protein localized mainly to the endoplasmic reticulum and Golgi apparatus. IRGQ hydrolyzes GTP to drive conformational changes that remodel intracellular membranes during immune activation and stress response. It is induced by interferon signaling and contributes to vesicle trafficking between endoplasmic reticulum and Golgi compartments.\u003cbr\u003e\u003cbr\u003eThe IRGQ gene is located on chromosome 19q13.33 and is expressed in immune-related tissues such as spleen, liver, and macrophages. Through its role in intracellular trafficking and vesicle fusion, IRGQ coordinates membrane remodeling events necessary for protein secretion and immune signaling.\u003cbr\u003e\u003cbr\u003ePathologically, IRGQ dysregulation has been associated with inflammatory and infectious diseases. Reduced IRGQ activity may impair vesicle transport, while overactivation can affect Golgi organization and cytokine secretion. Research using IRGQ antibody supports studies in GTPase biology, membrane dynamics, and immune regulation.\u003cbr\u003e\u003cbr\u003eIRGQ antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect small GTPases and membrane-associated enzymes. \u003cbr\u003e\u003cbr\u003eStructurally, Immunity-related GTPase family Q protein features conserved GTP-binding motifs (P-loop, switch I and II regions) and a C-terminal amphipathic helix that mediates membrane association. This antibody facilitates detailed study of IRGQ's GTPase-dependent mechanisms in host defense and vesicular transport.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IRGQ - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IRGQ - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IRGQ - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IRGQ - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IRGQ+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047313826157,"sku":"FY13147","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_a01f3e66-b5af-4038-b508-48a5d25b07a1.jpg?v=1782237100","url":"https:\/\/www.ebiohippo.com\/products\/irgq-antibody-immunity-related-gtpase-family-q-protein-bha17136049","provider":"BioHippo","version":"1.0","type":"link"}