{"product_id":"itgb7-antibody-integrin-beta-7-bha17135451","title":"ITGB7 Antibody \/ Integrin beta 7","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eITGB7 Antibody \/ Integrin beta 7 is a anti-ITGB7 Rabbit antibody Recombinant Rabbit Monoclonal clone 32I45 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human. Reported localization: Cytoplasm, cell membrane.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ITGB7\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 32I45, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eITGB7 antibody detects integrin beta 7, a transmembrane receptor subunit encoded by the ITGB7 gene. Integrins are heterodimeric receptors composed of alpha and beta chains that mediate cell adhesion, migration, and signaling. Integrin beta 7 pairs with alpha 4 or alpha E chains to form integrin alpha4beta7 and integrin alphaEbeta7. These receptors are critical for immune cell trafficking, mucosal homing, and lymphocyte adhesion to epithelial cells.\u003cbr\u003e\u003cbr\u003eITGB7 antibody is widely applied in immunology and inflammation research. Integrin alpha4beta7 directs lymphocytes to gut associated lymphoid tissues by binding to MAdCAM 1 on endothelial cells, while integrin alphaEbeta7 binds to E cadherin, supporting retention of lymphocytes in epithelial layers. By detecting ITGB7, researchers can study how integrins regulate lymphocyte homing and immune surveillance in mucosal tissues.\u003cbr\u003e\u003cbr\u003e In flow cytometry, ITGB7 antibody quantifies surface expression on lymphocytes, distinguishing subsets involved in mucosal immunity. Immunohistochemistry maps ITGB7 expression in gut and lymphoid tissues, while immunofluorescence highlights cell surface localization. Western blotting detects integrin beta 7 protein in immune cell lysates, providing complementary analysis across platforms.\u003cbr\u003e\u003cbr\u003eITGB7 is a therapeutic target in inflammatory bowel disease. Antibodies blocking integrin alpha4beta7 reduce lymphocyte trafficking to the gut and alleviate inflammation. Altered ITGB7 expression is also observed in autoimmune diseases and certain cancers, linking it to pathogenesis. By applying ITGB7 antibody, scientists can explore integrin biology in health and disease and evaluate therapeutic strategies targeting lymphocyte migration.\u003cbr\u003e\u003cbr\u003eBeyond mucosal immunity, integrin beta 7 contributes to immune responses in reproductive tissues, respiratory mucosa, and skin. It also participates in cytotoxic lymphocyte interactions with epithelial cells, influencing immune defense and tolerance. ITGB7 antibody therefore supports a wide range of studies in immunology, oncology, and inflammation.\u003cbr\u003e\u003cbr\u003eITGB7 antibody from\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ITGB7 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ITGB7 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ITGB7 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ITGB7 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ITGB7+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047292395885,"sku":"FY12548","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_20f62afa-8a3c-4a10-9b85-e8a4b722cc38.jpg?v=1772019313","url":"https:\/\/www.ebiohippo.com\/products\/itgb7-antibody-integrin-beta-7-bha17135451","provider":"BioHippo","version":"1.0","type":"link"}