{"product_id":"itm2c-antibody-integral-membrane-protein-2c-bha17135751","title":"ITM2C Antibody \/ Integral membrane protein 2C","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eITM2C Antibody \/ Integral membrane protein 2C is a anti-ITM2C Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e ITM2C\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eITM2C antibody detects Integral membrane protein 2C, a type II transmembrane protein implicated in neuronal differentiation, amyloid precursor protein (APP) metabolism, and synaptic maintenance. Encoded by the ITM2C gene on chromosome 11q25, this protein belongs to the BRICHOS superfamily, whose members are involved in protein folding, trafficking, and neuroprotection. ITM2C is highly expressed in the central nervous system, particularly in the hippocampus and cerebral cortex, where it contributes to synaptic function and neuroplasticity.\u003cbr\u003e\u003cbr\u003eStructurally, ITM2C contains a short cytoplasmic N-terminal tail, a single transmembrane domain, and a large luminal BRICHOS domain that assists in proper folding of amyloidogenic proteins. ITM2C interacts with APP and modulates its processing by influencing the activity of secretases, thereby reducing amyloid beta peptide production. This regulatory function positions ITM2C as a potential protective factor against neurodegenerative diseases such as Alzheimer's disease.\u003cbr\u003e\u003cbr\u003eThe ITM2C antibody is widely used in neuroscience and neurodegeneration research to study synaptic organization, APP metabolism, and BRICHOS domain biology. Western blot analysis detects a 30 kilodalton band corresponding to ITM2C, while immunofluorescence reveals Golgi and vesicular localization within neurons and glial cells. This antibody supports investigations into the cellular pathways controlling amyloid processing and synaptic stability.\u003cbr\u003e\u003cbr\u003eLoss or dysregulation of ITM2C has been associated with cognitive decline and neuroinflammation. Reduced expression leads to impaired APP trafficking and enhanced amyloid accumulation, while overexpression protects against oxidative and excitotoxic stress. Beyond the brain, ITM2C is expressed in pancreatic islets, suggesting additional roles in endocrine regulation. The ITM2C antibody provides a powerful tool for elucidating mechanisms of protein homeostasis and synaptic maintenance in health and disease.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=ITM2C - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=ITM2C - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=ITM2C - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/ITM2C - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=ITM2C+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047304159597,"sku":"FY12849","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_cee67af5-1b57-471f-8168-cf9b75dcda3a.jpg?v=1782237053","url":"https:\/\/www.ebiohippo.com\/products\/itm2c-antibody-integral-membrane-protein-2c-bha17135751","provider":"BioHippo","version":"1.0","type":"link"}