{"product_id":"ivns1abp-antibody-influenza-virus-ns1a-binding-protein-bha17135371","title":"IVNS1ABP Antibody \/ Influenza virus NS1A-binding protein","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eIVNS1ABP Antibody \/ Influenza virus NS1A-binding protein is a anti-IVNS1ABP Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat. Reported localization: Cytoplasmic, Nuclear.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e IVNS1ABP\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Lyophilized\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, IHC, IF, ICC\/IF, FACS, ELISA\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eIVNS1ABP antibody detects Influenza virus NS1A-binding protein, a multifunctional nuclear protein involved in RNA processing, chromatin remodeling, and stress responses. IVNS1ABP interacts with the influenza virus NS1A protein, modulating viral replication, but also has critical host cellular functions in normal physiology. It associates with transcriptional and splicing machinery, influences ribonucleoprotein complex assembly, and regulates cell growth and differentiation. The IVNS1ABP antibody is widely employed in studies of host-virus interactions, RNA metabolism, and nuclear architecture.\u003cbr\u003e\u003cbr\u003eIVNS1ABP is encoded by the IVNS1ABP gene on human chromosome 1p13.3 and produces a protein of approximately 72 kDa. The protein contains multiple WD40 repeats that mediate protein-protein interactions and a nuclear localization signal that directs it to nucleoplasmic and speckle regions. IVNS1ABP interacts with heterogeneous nuclear ribonucleoproteins (hnRNPs), transcriptional regulators, and chromatin remodelers such as BRG1. Its diverse set of interactions positions it as a hub protein coordinating mRNA maturation and transport.\u003cbr\u003e\u003cbr\u003eResearch using the IVNS1ABP antibody shows that it contributes to the regulation of pre-mRNA splicing, ribosome biogenesis, and stress granule dynamics. Upon viral infection, IVNS1ABP binds to influenza NS1A protein, enhancing viral mRNA processing and nuclear export. However, under normal conditions, it supports cell survival and proliferation through stabilization of specific RNA-protein complexes. Western blot analysis typically identifies a band near 90 kDa, while immunofluorescence reveals nuclear and nucleolar staining. Loss of IVNS1ABP disrupts splicing patterns and increases sensitivity to stress-induced apoptosis.\u003cbr\u003e\u003cbr\u003eBeyond viral interactions, IVNS1ABP is linked to cell differentiation and cytoskeletal organization. It modulates actin dynamics by interacting with profilin and other actin-binding proteins, connecting nuclear signaling with cytoplasmic architecture. Dysregulation of IVNS1ABP has been implicated in developmental disorders and certain cancers.\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunohistochemistry:\u003c\/strong\u003e map target signal in tissue context and compare regions\/phenotypes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlow cytometry:\u003c\/strong\u003e quantify target-positive populations and signal shifts at single-cell resolution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eELISA:\u003c\/strong\u003e support antibody-based quantification in assay formats where applicable.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=IVNS1ABP - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=IVNS1ABP - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=IVNS1ABP - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/IVNS1ABP - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=IVNS1ABP+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53047290069357,"sku":"FY12468","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_7d307eab-c1bc-4f48-bc8d-301529e98820.jpg?v=1772019336","url":"https:\/\/www.ebiohippo.com\/products\/ivns1abp-antibody-influenza-virus-ns1a-binding-protein-bha17135371","provider":"BioHippo","version":"1.0","type":"link"}