{"product_id":"jeko-1-cell-bhc11101320","title":"JeKo-1 cell","description":"The JeKo-1 cell line is an established human mantle cell lymphoma (MCL) cell line derived from an adult patient. Mantle cell lymphoma is a type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1 due to the t(11;14)(q13;q32) chromosomal translocation. JeKo-1 cells exhibit this hallmark genetic aberration, making them a valuable model for studying the pathophysiology of MCL and testing therapeutic agents targeting the cyclin D1 pathway. These cells grow in suspension and possess a doubling time that facilitates robust experimental use in various high-throughput screening applications.\n\nJeKo-1 cells are particularly useful in research focused on the molecular mechanisms of MCL, including the exploration of B-cell receptor (BCR) signaling pathways, apoptosis resistance, and drug resistance mechanisms. Additionally, this cell line serves as a model for studying the interaction between tumor cells and the microenvironment, especially in the context of lymphoid malignancies. Due to its well-characterized genetic background and consistent behavior in vitro, JeKo-1 is frequently utilized in the development and testing of novel anti-cancer compounds, particularly those aimed at overcoming chemoresistance in MCL.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101320\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950212903277,"sku":"305078","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/jeko-1_20_281_29_1920x1920_ca9db71c-6b66-4547-8ec4-274166e6f9d2.jpg?v=1769069117","url":"https:\/\/www.ebiohippo.com\/products\/jeko-1-cell-bhc11101320","provider":"BioHippo","version":"1.0","type":"link"}