{"product_id":"k11-linked-polyubiquitin-specific-antibody-2a3-2e6-bha21405460","title":"K11-Linked Polyubiquitin-Specific Antibody (2A3\/2E6)","description":"\u003cp\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003cbr\u003eAntibody against K11-Linked Polyubiquitin-Specific (Polyubiquitin-C) for research detection of protein expression and localization.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eTarget biology\u003c\/strong\u003e\u003cbr\u003ePolyubiquitin-C participates in ubiquitin-mediated protein regulation, where ubiquitin conjugation can alter substrate stability, localization or signaling. Ubiquitin pathway components are widely studied in proteostasis, stress responses, innate immunity and cancer.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExpected localization\u003c\/strong\u003e\u003cbr\u003eCommonly cytosolic and\/or nuclear with enrichment at specific complexes depending on substrates.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eResearch context\u003c\/strong\u003e\u003cbr\u003eThis target is frequently studied in the context of \u003cem\u003eProtein Homeostasis \u0026amp; Degradation\u003c\/em\u003e research. Application suitability (e.g., ELISA) is indicated in the specifications; conditions should be optimized by titration. Species reactivity information is provided in the specifications (reported: Human).\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eRecommended experimental notes\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\u003cli\u003eFor ELISA, ensure capture\/detection antibody compatibility and run a standard curve; verify sample matrix effects with spike-and-recovery and dilution linearity.\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eControls \u0026amp; interpretation\u003c\/strong\u003e\u003cbr\u003eWhere possible, confirm specificity using genetic perturbation (KO\/KD\/CRISPR), peptide competition (if applicable), or an orthogonal readout. Include a negative control sample expected to express low\/none of K11-Linked Polyubiquitin-Specific, and a positive control sample known to express K11-Linked Polyubiquitin-Specific.\u003c\/p\u003e\u003cp\u003e\u003cem\u003eFor research use only. Not for diagnostic procedures.\u003c\/em\u003e\u003c\/p\u003e","brand":"Biohippo Inc","offers":[{"title":"50 ug","offer_id":53036928205165,"sku":"HY324043-50UG","price":191.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53037529366893,"sku":"HY324043-100UG","price":370.0,"currency_code":"USD","in_stock":true},{"title":"1 mg","offer_id":53037529399661,"sku":"HY324043-1MG","price":1858.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/HY324043-SDSPAGE-1.jpg?v=1771745946","url":"https:\/\/www.ebiohippo.com\/products\/k11-linked-polyubiquitin-specific-antibody-2a3-2e6-bha21405460","provider":"BioHippo","version":"1.0","type":"link"}