{"product_id":"kasumi-1-cell-bhc11100540","title":"Kasumi-1 cell","description":"The Kasumi-1 cell line was derived from the peripheral blood of a 7-year-old Japanese boy with acute myeloid leukemia (AML), specifically the FAB M2 subtype, during a relapse following bone marrow transplantation. This cell line is a valuable resource for researchers studying hematologic malignancies, especially those involving the t(8;21) chromosomal translocation. This translocation leads to the formation of the AML1-ETO fusion gene, a critical factor in certain subtypes of AML. Kasumi-1 cells thus serve as an essential model for investigating the molecular mechanisms of AML and testing potential therapeutic approaches.\n\nKasumi-1 cells possess characteristics of both myeloid and macrophage lineages, making them particularly useful for studies on myeloid differentiation. These cells can be induced to differentiate into macrophage-like cells when cultured with phorbol 12-myristate 13-acetate (TPA), providing a robust system for exploring the pathways involved in myeloid lineage commitment and differentiation. This differentiation capacity enhances the utility of Kasumi-1 cells in research focused on both AML biology and broader myeloid cell development processes.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100540\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213198189,"sku":"300226","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/Kasumi-1_20P1_2010x01_20080525_ch00_1920x1920_0daa8898-0d6c-4249-b507-feac732643d9.jpg?v=1769069119","url":"https:\/\/www.ebiohippo.com\/products\/kasumi-1-cell-bhc11100540","provider":"BioHippo","version":"1.0","type":"link"}