{"product_id":"kctd9-antibody-potassium-channel-tetramerization-domain-containing-protein-9-bha17136198","title":"KCTD9 Antibody \/ Potassium channel tetramerization domain containing protein 9","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eKCTD9 Antibody \/ Potassium channel tetramerization domain containing protein 9 is a anti-KCTD9 Rabbit antibody Recombinant Rabbit Monoclonal clone 29K82 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Human.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KCTD9\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntibody details:\u003c\/strong\u003e Rabbit, Recombinant Rabbit Monoclonal, clone 29K82, isotype Rabbit IgG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFormat:\u003c\/strong\u003e Liquid\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplications (as listed):\u003c\/strong\u003e WB, ICC, IF\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background\u003c\/h2\u003e\u003cdiv\u003eKCTD9 antibody detects Potassium channel tetramerization domain containing protein 9, encoded by the KCTD9 gene. Potassium channel tetramerization domain containing protein 9 is a member of the KCTD family of proteins that share a BTB\/POZ domain involved in protein-protein interactions. KCTD9 antibody provides researchers with an important reagent for studying immune regulation, apoptosis, and signaling pathways.\u003cbr\u003e\u003cbr\u003eAlthough originally identified through sequence similarity to potassium channel subunits, KCTD9 does not form ion channels. Research using KCTD9 antibody has demonstrated that it functions as an adaptor protein in ubiquitin ligase complexes, targeting substrates for ubiquitination and degradation. By regulating protein turnover, KCTD9 influences signaling cascades and cellular homeostasis.\u003cbr\u003e\u003cbr\u003eStudies with KCTD9 antibody have revealed important roles in immune function. KCTD9 has been implicated in natural killer cell activation, where it regulates cytokine production and cytotoxic responses. Dysregulation of KCTD9 expression impairs antiviral immunity and contributes to immune mediated pathology. This highlights its relevance in both protective and pathogenic immune responses.\u003cbr\u003e\u003cbr\u003eKCTD9 has also been linked to apoptosis. Research using KCTD9 antibody has shown that altered expression modulates mitochondrial pathways of cell death, influencing susceptibility to stress and chemotherapeutic agents. These findings suggest that KCTD9 participates in cross talk between ubiquitin signaling and apoptosis pathways.\u003cbr\u003e\u003cbr\u003eDysregulation of Potassium channel tetramerization domain containing protein 9 has been associated with disease. Elevated expression is observed in inflammatory conditions and cancers, while reduced expression may compromise immune defense. These context dependent roles underscore the importance of precise regulation of KCTD9 levels.\u003cbr\u003e\u003cbr\u003eKCTD9 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects endogenous levels across tissues, immunohistochemistry reveals localization in immune organs, and immunofluorescence demonstrates cytoplasmic distribution. These experimental applications make KCTD9 antibody a versatile reagent in signaling and immunology research.\u003cbr\u003e\u003cbr\u003eBy supplying validated KCTD9 antibody reagents,\u003c\/div\u003e\u003ch2\u003eResearch relevance and current trends\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eConnecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).\u003c\/li\u003e\n\u003cli\u003eConsidering isoforms and post-translational regulation when interpreting protein-level changes.\u003c\/li\u003e\n\u003cli\u003eComparing results across species and model systems with matched controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWestern blotting:\u003c\/strong\u003e compare relative abundance and activation-state changes across conditions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunofluorescence:\u003c\/strong\u003e visualize subcellular distribution and cell-to-cell heterogeneity.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eInterpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.\u003c\/p\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eSignal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.\u003c\/li\u003e\n\u003cli\u003eSpecies differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eAntibody notes:\u003c\/strong\u003e Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.\u003c\/p\u003e\u003c!-- Sources (internal): - UniProt search — UniProt — https:\/\/www.uniprot.org\/uniprotkb?query=KCTD9 - NCBI Gene search — NCBI — https:\/\/www.ncbi.nlm.nih.gov\/gene\/?term=KCTD9 - Ensembl search — Ensembl — https:\/\/www.ensembl.org\/Multi\/Search\/Results?q=KCTD9 - Human Protein Atlas search — HPA — https:\/\/www.proteinatlas.org\/search\/KCTD9 - PubMed (review) — NLM — https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=KCTD9+review --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg\/ml BSA \/ 100 ul","offer_id":53047321592173,"sku":"FY13296","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_5462bf9e-c7f2-4459-b221-01adffb55f18.jpg?v=1772019422","url":"https:\/\/www.ebiohippo.com\/products\/kctd9-antibody-potassium-channel-tetramerization-domain-containing-protein-9-bha17136198","provider":"BioHippo","version":"1.0","type":"link"}