{"product_id":"keap1-antibody-kelch-like-ech-associated-protein-1-bha17135009","title":"KEAP1 Antibody \/ Kelch-like ECH-associated protein 1","description":"\u003ch2\u003eOverview\u003c\/h2\u003e\u003cp\u003eKEAP1 Antibody \/ Kelch-like ECH-associated protein 1 is an antibody targeting \u003cstrong\u003eKEAP1\u003c\/strong\u003e. Host: \u003cstrong\u003eRabbit\u003c\/strong\u003e. Polyclonal. Format: Lyophilized. Applications: WB, ICC, IF, FACS, ELISA.\u003c\/p\u003e\u003ch2\u003eKey elements and design rationale\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTarget:\u003c\/strong\u003e KEAP1.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunogen:\u003c\/strong\u003e E.coli-derived human KEAP1 recombinant protein (Position: K84-K312) was used as the immunogen for the KEAP1 antibody..\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpecies reactivity:\u003c\/strong\u003e Human, Mouse, Rat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConjugate:\u003c\/strong\u003e Unconjugated (no label listed).\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eBiological background (from provided description)\u003c\/h2\u003e\u003cp\u003eKEAP1 antibody is designed to target Kelch-like ECH-associated protein 1, a critical regulator of cellular redox balance and stress response. The KEAP1 protein functions as a substrate adaptor protein within a Cullin 3-based E3 ubiquitin ligase complex, where it plays a central role in mediating the ubiquitination and subsequent degradation of nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2).\u003c\/p\u003e\u003ch2\u003eCommon research applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eWB:\u003c\/strong\u003e relative abundance and band pattern assessment using appropriate controls.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIF\/ICC:\u003c\/strong\u003e subcellular localization imaging with proper background controls.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eNotes for experimental interpretation\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eAccount for isoforms, paralogs, and post-translational modifications when interpreting signal.\u003c\/li\u003e\n\u003cli\u003eSupport specificity with biological controls (e.g., KO\/KD where available) and technical controls (e.g., secondary-only\/isotype).\u003c\/li\u003e\n\u003c\/ul\u003e\u003c!-- Sources (internal): - UniProt Knowledgebase (UniProt) – https:\/\/www.uniprot.org\/ - NCBI Gene (NIH\/NLM) – https:\/\/www.ncbi.nlm.nih.gov\/gene\/ - ZFIN – https:\/\/zfin.org\/ - Ensembl – https:\/\/www.ensembl.org\/ - Nature Methods (2015): A proposal for validation of antibodies – https:\/\/www.nature.com\/articles\/nmeth.3230 --\u003e","brand":"NSJ Bioreagents","offers":[{"title":"Adding 0.2 ml of distilled water will yield a concentration of 500 ug\/ml \/ 100 ug","offer_id":53046715580781,"sku":"FY12106","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/get_image_348e6f69-2dc5-4071-9230-8aec66e98e94.jpg?v=1782236965","url":"https:\/\/www.ebiohippo.com\/products\/keap1-antibody-kelch-like-ech-associated-protein-1-bha17135009","provider":"BioHippo","version":"1.0","type":"link"}