{"product_id":"kera-308-cell-bhc11100457","title":"Kera-308 cell","description":"The Kera-308 cell line, established from adult mouse skin keratinocytes, offers a versatile model for studying the intricate processes of skin physiology, particularly wound healing and keratinocyte function. This cell line demonstrates a remarkable ability to up-regulate keratin expression, including wound-induced keratin types such as Krt6a, under specific conditions such as treatment with Morus alba root extract. The responsiveness of Kera-308 cells to phorbol 12-myristate 13-acetate (PMA) highlights their utility in investigating the cellular mechanisms underlying skin repair and regeneration.\nA standout feature of Kera-308 cells is their dose-dependent proliferation response, which can be significantly enhanced by external stimuli like Morus alba root extract. This characteristic makes Kera-308 an excellent tool for probing the molecular underpinnings of keratinocyte proliferation and differentiation in response to therapeutic agents.\nMoreover, the transcriptional profile of Kera-308 cells in wound healing scenarios, particularly their up-regulated keratin filament and CXCL12\/CXCR4 signaling, provides invaluable insights into the cellular and molecular dynamics at play during skin repair. The involvement of these signaling pathways underscores the relevance of Kera-308 cells in exploring new therapeutic strategies for enhancing wound healing and treating skin disorders.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100457\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213329261,"sku":"400429","price":800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/kera-308-_284_29_1920x1920_3bee3ceb-fcfb-42b9-ac23-77c16e711b83.jpg?v=1769069120","url":"https:\/\/www.ebiohippo.com\/products\/kera-308-cell-bhc11100457","provider":"BioHippo","version":"1.0","type":"link"}