{"product_id":"khos-np-cell-bhc11100683","title":"KHOS-NP cell","description":"KHOS-NP is a cell line derived from the HOS cell line through transformation with the Kirsten murine sarcoma virus (Ki-MSV). The transformation process has resulted in a highly tumorigenic cell line that is characterized by several distinct properties, making it valuable for specific research applications. Notably, the KHOS-NP cells are particularly useful for producing MSV pseudotypes with various ecotropic and xenotropic murine leukemia viruses, which is of interest in studies focused on viral replication, oncogenesis, and related pathways.\n\nKHOS-NP cells exhibit adherent growth properties and are derived from the bone tissue of a white, female adult. The cells carry the Ki-MSV genome but do not produce infectious virus particles or viral antigens, making them safe for certain in vitro research settings where infectious viral production would be a concern. Despite this, the KHOS-NP cells maintain a high saturation density and have a high plating efficiency in soft agar, demonstrating robust proliferative and anchorage-independent growth characteristics, which are typical of transformed and tumorigenic cell lines.\n\nIn vivo, KHOS-NP cells are highly tumorigenic, with a 100% frequency of tumor formation observed in nude mice within 21 days post-inoculation when injected subcutaneously with 107 cells. These properties make the KHOS-NP cell line a valuable model for studying sarcoma development, tumor biology, and the molecular mechanisms underlying oncogenesis. However, it is essential to note that KHOS-NP cells are not suitable for therapeutic or in vivo applications, and their use should be restricted to controlled experimental conditions in a research setting.\n\u003cp style=\"display:none\"\u003eSKU:BHC11100683\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213558637,"sku":"300235","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/khos-np-_281_29_1920x1920_3f63eb16-3d4d-4139-9aa4-cec9e8ce8e3b.jpg?v=1769069122","url":"https:\/\/www.ebiohippo.com\/products\/khos-np-cell-bhc11100683","provider":"BioHippo","version":"1.0","type":"link"}