{"product_id":"kms-12-bm-cell-bhc11101502","title":"KMS-12-BM cell","description":"The KMS-12-BM cell line is a human myeloma cell line established from the bone marrow of a patient with non-producing multiple myeloma. This cell line represents an immature plasmacytoid stage of B-cell differentiation, characterized by the expression of surface markers CD20, CD38, and PCA-1, but a lack of immunoglobulin production. The cells are notable for their distorted morphology, with many showing multinuclear and giant characteristics. Ultrastructurally, KMS-12-BM cells possess well-developed rough endoplasmic reticulum and ovoid eccentric nuclei with peripheral chromatin distribution, typical of plasmacytoid cells. KMS-12-BM cells exhibit a chromosomal abnormality, particularly a reciprocal translocation t(11;14)(q13;q32), which is often associated with multiple myeloma. These cells also display a broad range of chromosomal numbers, from hypodiploid to polyploid, indicating significant genomic instability. Unlike its counterpart KMS-12-PE, the KMS-12-BM line does not produce amylase, and it lacks immunoglobulin secretion or surface expression, making it suitable for studies involving immunoglobulin-nonproducing myeloma. Additionally, it shows low cloning efficiency in soft agar culture conditions, with less than 0.1% colony formation, and has no tumorigenic properties when injected into nude mice.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101502\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213755245,"sku":"300287","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KM-12_20P3_2010x01_20270824_ch00_1920x1920_a9f97283-be97-4d24-9eb7-aba0427092a0.jpg?v=1769069124","url":"https:\/\/www.ebiohippo.com\/products\/kms-12-bm-cell-bhc11101502","provider":"BioHippo","version":"1.0","type":"link"}