{"product_id":"kms-12-pe-cell-bhc11101501","title":"KMS-12-PE cell","description":"The KMS-12-PE cell line, established from the pleural effusion of the same patient, differs significantly from KMS-12-BM in several aspects. KMS-12-PE cells represent a more terminally differentiated plasma cell stage, as indicated by the absence of CD20 but continued expression of CD38 and PCA-1. A striking feature of KMS-12-PE is its ability to ectopically produce and secrete a salivary type of amylase, both in the patient’s pleural effusion and in culture, making it unique among human myeloma cell lines. This phenomenon is associated with a chromosomal deletion near the region where the amylase gene is located, specifically del(1)(p22→pter), observed in a significant proportion of KMS-12-PE cells. Despite these distinct differences, both KMS-12-PE and KMS-12-BM share the same clonal marker, the translocation t(11;14)(q13;q32), which is common in myeloma cases. However, KMS-12-PE cells show fewer chromosomal abnormalities than KMS-12-BM and tend to be hypodiploid. Like KMS-12-BM, KMS-12-PE does not produce immunoglobulins, either in surface or secretory form, even though the cells have well-developed endoplasmic reticulum. The lack of tumorigenicity in both cell lines, despite their aggressive in vitro growth, and their stable long-term proliferation in serum-free medium make them valuable tools for studying myeloma biology, particularly in the context of non-Ig-producing myeloma.\n\u003cp style=\"display:none\"\u003eSKU:BHC11101501\u003c\/p\u003e","brand":"Cytion","offers":[{"title":"1 cryovial","offer_id":52950213788013,"sku":"300286","price":395.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0949\/7424\/7277\/files\/KM-12_20P3_2010x01_20270824_ch00_1920x1920_c69cc7a5-2cc6-4ffe-8695-1e1fcb541a1b.jpg?v=1769069124","url":"https:\/\/www.ebiohippo.com\/products\/kms-12-pe-cell-bhc11101501","provider":"BioHippo","version":"1.0","type":"link"}